The global pharmaceutical industry relies heavily on a robust and efficient supply chain for its raw materials and intermediates. China has emerged as a dominant player in this arena, offering a vast array of chemical compounds at competitive prices. For procurement managers and research scientists, understanding the factors influencing the price and availability of key pharmaceutical intermediates, such as (E)-3-[2-(Pyridin-2-yl)ethenyl]-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-amine (CAS 886230-76-8), is crucial for effective sourcing strategies.

Several elements contribute to the overall price of a pharmaceutical intermediate. Firstly, the complexity of its synthesis plays a significant role. Compounds requiring multi-step synthesis, specialized reagents, or stringent purification processes will naturally command a higher price. (E)-3-[2-(Pyridin-2-yl)ethenyl]-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-amine, with its intricate molecular structure (C19H20N4O), falls into this category. Secondly, the scale of production directly impacts cost. Larger production runs typically benefit from economies of scale, leading to lower per-unit prices. For buyers needing significant quantities, negotiating bulk pricing with a reliable manufacturer in China is often the most economical approach.

Availability is another critical consideration. While China boasts numerous chemical manufacturers, the supply of specific intermediates can fluctuate due to factors such as raw material availability, regulatory changes, and global demand. For a compound like CAS 886230-76-8, which serves as a precursor for important drugs like Axitinib, maintaining a steady supply is paramount. Buyers should actively seek out manufacturers with a proven track record of consistent production and a solid understanding of supply chain management.

When searching for this pharmaceutical intermediate, using keywords like 'CAS 886230-76-8 price,' 'buy pharmaceutical intermediate China,' or 'supplier (E)-3-[2-(Pyridin-2-yl)ethenyl]-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-amine' will help identify potential vendors. It is recommended to request detailed quotations that include purity specifications, minimum order quantities, and delivery terms. Furthermore, understanding the payment options available (L/C, T/T, PayPal, etc.) and the Incoterms (FOB, CFR, CIF) is essential for a smooth transaction.

Ultimately, the goal for any procurement professional is to secure a reliable supply of high-quality pharmaceutical intermediates at a competitive price. By thoroughly researching manufacturers, understanding the cost drivers, and establishing clear communication channels, businesses can effectively navigate the Chinese chemical market to meet their demanding needs for compounds like (E)-3-[2-(Pyridin-2-yl)ethenyl]-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-amine.