In the vast landscape of chemical synthesis, understanding the properties and applications of key intermediates is fundamental for efficient research and development. This article focuses on 5-Bromoisophthalonitrile, a compound identified by CAS number 160892-07-9, highlighting its importance as a versatile chemical building block. We aim to equip procurement specialists and chemists with the necessary information to source this compound effectively, emphasizing its role in various industrial and research applications.

Chemical Profile of 5-Bromoisophthalonitrile

5-Bromoisophthalonitrile, also known by synonyms such as 5-Bromobenzene-1,3-dicarbonitrile, is an aromatic compound characterized by the presence of two nitrile (-CN) functional groups and a bromine (-Br) substituent on a benzene ring. Its molecular formula is C8H3BrN2, with a molecular weight of approximately 207.03 g/mol. Typically supplied as a white to yellowish solid, its purity, commonly specified at 97% minimum, is a crucial parameter for its intended applications.

The structure of 5-Bromoisophthalonitrile makes it a highly versatile intermediate. The nitrile groups are reactive towards reduction and nucleophilic addition, while the bromine atom is amenable to various metal-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) and nucleophilic aromatic substitutions. This dual reactivity opens up numerous pathways for synthesizing complex organic molecules.

Synthesis Routes and Industrial Production

The synthesis of 5-Bromoisophthalonitrile generally involves the electrophilic bromination of isophthalonitrile. Common industrial methods include:

  • Direct Bromination: Using molecular bromine (Br2) in the presence of catalysts like iron(III) bromide (FeBr3) or aluminum chloride (AlCl3).
  • N-Bromosuccinimide (NBS) Bromination: A safer alternative that often uses polar solvents and can be facilitated by acid catalysis.
  • Sandmeyer Reaction: Applicable if starting from an amino-substituted precursor.

Manufacturers focus on optimizing these routes to achieve high yields and purity while managing costs and environmental impact. The efficiency of these synthesis methods is key to making 5-Bromoisophthalonitrile an economically viable intermediate.

Key Applications and Market Demand

The demand for 5-Bromoisophthalonitrile is driven by its broad utility across several sectors:

  • Pharmaceuticals: It serves as a crucial intermediate in the synthesis of various APIs and medicinal compounds.
  • Agrochemicals: Used in the development of pesticides, herbicides, and other crop protection agents.
  • Advanced Materials: Acts as a monomer or linker for MOFs (Metal-Organic Frameworks) and COFs (Covalent Organic Frameworks), used in gas separation, catalysis, and energy storage.
  • Research and Development: A fundamental building block for organic chemists exploring new reactions and molecular structures.

Where to Buy 5-Bromoisophthalonitrile: Partnering with NINGBO INNO PHARMCHEM CO.,LTD.

For businesses and researchers requiring high-quality 5-Bromoisophthalonitrile, choosing a reliable supplier is paramount. NINGBO INNO PHARMCHEM CO.,LTD. is a professional chemical company based in China, committed to providing premium chemical intermediates. As your trusted 5-Bromoisophthalonitrile supplier, we offer:

  • Guaranteed Quality: Our products meet strict purity standards, ensuring optimal performance in your applications.
  • Competitive Manufacturer Pricing: We offer direct-from-manufacturer pricing, particularly advantageous for bulk purchases. Request a quote for detailed pricing information.
  • Efficient Logistics: We manage the complexities of chemical shipping to ensure timely delivery.
  • Dedicated Customer Support: Our team is available to assist with inquiries and provide technical support.

To secure a consistent and high-quality supply of 5-Bromoisophthalonitrile, consider NINGBO INNO PHARMCHEM CO.,LTD. as your preferred partner. We invite you to buy 5-Bromoisophthalonitrile from us and leverage our expertise to advance your projects.