In the complex landscape of chemical synthesis, having access to reliable and versatile intermediates is crucial for innovation. 1-Bromo-4-chloro-2-fluoro-5-methoxy-benzene (CAS: 146447-18-9) is a notable organic building block that has garnered significant attention due to its extensive applications, particularly within the pharmaceutical and agrochemical sectors. This article explores its chemical profile, key uses, and provides guidance for procurement professionals.

Chemical Profile and Reactivity

1-Bromo-4-chloro-2-fluoro-5-methoxy-benzene is characterized by its highly substituted aromatic ring, featuring a bromine atom, a chlorine atom, a fluorine atom, and a methoxy group. This unique combination confers several important properties:

  • Versatile Reactivity: The multiple halogen substituents offer diverse opportunities for chemical transformations. These include participation in palladium-catalyzed cross-coupling reactions (such as Suzuki, Stille, and Heck couplings), nucleophilic aromatic substitutions, and metallation reactions. These pathways are fundamental for building complex organic molecules.
  • Strategic Functionalization: The distinct electronic effects and steric profiles of bromine, chlorine, and fluorine allow for regioselective reactions, enabling chemists to introduce specific functionalities at desired positions on the benzene ring.
  • Physical Attributes: Typically presented as a solid, its physical state and melting point (72-76 °C) make it manageable for both laboratory and industrial synthesis processes.

Core Applications in Key Industries

The demand for 1-Bromo-4-chloro-2-fluoro-5-methoxy-benzene is primarily driven by its utility in:

  • Pharmaceutical Development: As a critical intermediate, it is instrumental in the synthesis of novel pharmaceuticals. The halogen atoms can modulate a drug candidate's pharmacokinetic properties, such as metabolic stability and receptor binding, thereby enhancing its therapeutic efficacy. Professionals looking to buy pharmaceutical intermediates will find this compound invaluable.
  • Agrochemicals: It is employed in the formulation of advanced agrochemicals, including potent herbicides and fungicides. Its structure can impart specific biological activities crucial for crop protection and yield improvement. For those seeking agrochemical intermediates for sale, this compound offers significant synthetic advantages.
  • Materials Science: The compound's unique properties also find application in the creation of advanced materials with tailored electronic and optical characteristics, relevant for fields like organic electronics.

Sourcing Strategies for Businesses

For businesses requiring this chemical, identifying a dependable chemical supplier is paramount. NINGBO INNO PHARMCHEM CO.,LTD. is a leading chemical manufacturer specializing in high-quality organic intermediates. We provide competitive chemical pricing and ensure product consistency, essential for large-scale production. We strongly advise engaging with established chemical manufacturers in China to secure reliable supply chains and high-purity materials. Please feel free to contact us for quotes, product availability, or custom synthesis requirements to support your research and development efforts.