In the realm of pharmaceutical manufacturing, the quality of raw materials and intermediates directly dictates the efficacy and safety of the final drug product. For statin medications, such as Rosuvastatin Calcium, which are crucial in managing cholesterol levels, the synthesis pathway involves several key chemical building blocks. One such vital intermediate is [[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]methyl]triphenylphosphonium Bromide, identified by its CAS number 154057-58-6.

The Chemical Profile and Application

This phosphonium salt is characterized by its chemical structure, which includes a quinoline core, a fluorophenyl moiety, and a triphenylphosphonium group. It typically appears as a white to off-white powder, with a purity assay of ≥98.0%. These specifications are critical for its use in pharmaceutical synthesis, where precision and purity are paramount. The compound serves as a precursor in Wittig reactions or similar olefination processes, which are essential for constructing the specific side chain of Rosuvastatin Calcium. The stereochemistry and integrity of this intermediate directly influence the quality and pharmacological activity of the final API.

Beyond its chemical properties, understanding the sourcing and handling of this intermediate is vital for procurement professionals and R&D scientists. Factors such as low loss on drying (≤1.0%) indicate proper manufacturing and storage, preventing degradation and ensuring consistent performance in synthesis. Reliable manufacturers maintain stringent quality control measures throughout the production process.

Sourcing Strategy for Pharmaceutical Manufacturers

When sourcing [[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]methyl]triphenylphosphonium Bromide, pharmaceutical companies should prioritize:

  • Supplier Credibility: Partner with established manufacturers known for their expertise in fine chemicals and pharmaceutical intermediates.
  • Quality Assurance: Always request detailed Certificates of Analysis (CoA) and ensure the supplier's Quality Management System (QMS) aligns with industry standards.
  • Cost-Effectiveness: Obtain competitive quotes, especially for bulk purchases, to ensure the economic viability of the production process. Inquire about the best price for your required quantity.
  • Technical Support: Engage with suppliers who offer technical assistance and clear documentation (e.g., MSDS) to facilitate smooth integration into your manufacturing workflow.

NINGBO INNO PHARMCHEM CO.,LTD. is a leading manufacturer and supplier committed to providing high-quality pharmaceutical intermediates. We offer [[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]methyl]triphenylphosphonium Bromide, meeting the rigorous demands of the pharmaceutical industry. Our goal is to be your reliable partner for chemical sourcing, ensuring you receive precisely what you need, when you need it. Contact us today to learn more about our product offerings and how we can support your manufacturing objectives.