The production of modern pharmaceuticals is a testament to the precision and complexity of organic chemistry. For cardiovascular drugs like Rosuvastatin Calcium, which helps manage high cholesterol, the synthesis relies on a series of meticulously chosen chemical intermediates. Among these, [[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]methyl]triphenylphosphonium Bromide (CAS: 154057-58-6) stands out as a particularly important compound. This article delves into its function, specifications, and the considerations for sourcing it effectively.

Understanding the Synthesis Pathway

[[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]methyl]triphenylphosphonium Bromide is an organophosphorus compound that functions as a phosphonium ylide precursor. In the context of Rosuvastatin Calcium synthesis, it is commonly utilized in a Wittig reaction. This reaction is a cornerstone in creating alkene functionalities, and in this specific pharmaceutical synthesis, it's employed to construct a key part of the statin's characteristic heptenoic acid side chain. The precise arrangement and purity of this intermediate are critical for achieving the desired stereochemistry and overall structure of Rosuvastatin Calcium.

Manufacturers typically provide this intermediate with an assay of ≥98.0% and describe its appearance as a white to off-white powder. Other important specifications often include a low percentage of loss on drying, indicating minimal moisture content. These quality parameters are not arbitrary; they directly influence the success of subsequent reaction steps, the purity of the final API, and ultimately, the drug's therapeutic profile. For procurement teams, ensuring these specifications are met by the supplier is a non-negotiable aspect of the purchasing process.

Partnering with a Reputable Manufacturer

For pharmaceutical companies aiming to secure a stable supply of [[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]methyl]triphenylphosphonium Bromide, choosing the right manufacturer is paramount. A reputable supplier will not only meet the required purity standards but also offer competitive pricing and consistent availability. Key considerations when evaluating a manufacturer include:

  • Technical Capability: Does the manufacturer have a strong track record in synthesizing complex intermediates?
  • Quality Control: Are robust QC/QA systems in place, with detailed batch analysis available?
  • Scalability: Can the manufacturer reliably supply the required volumes for commercial production?
  • Regulatory Compliance: Does the manufacturer adhere to relevant industry standards and provide necessary documentation?

NINGBO INNO PHARMCHEM CO.,LTD. is committed to being a leading supplier of essential pharmaceutical intermediates, including CAS 154057-58-6. We prioritize quality, reliability, and customer service to support your production needs. If you are looking to purchase this critical compound or require more information on our product offerings, please reach out to us. We are a trusted source for your chemical sourcing needs, providing high-quality intermediates from China.