The pharmaceutical industry relies heavily on a robust supply chain of specialized chemical intermediates to produce life-saving medications. Among these, (3R,4S)-3-Hydroxy-4-phenylazetidin-2-one, known by its CAS number 132127-34-5, plays a critical role in the synthesis of major anticancer drugs, namely Paclitaxel and Docetaxel. For pharmaceutical manufacturers and research institutions, understanding this compound's characteristics and ensuring a reliable supply source is paramount.

The Chemical Profile of a Vital Intermediate

(3R,4S)-3-Hydroxy-4-phenylazetidin-2-one is a chiral molecule with the chemical formula C9H9NO2 and a molecular weight of 163.17. It is characterized as a white solid, with a defined melting point range of 187-188°C, indicating good stability for handling and storage. Its density is reported as 1.308, and its refractive index is 1.612. These specific physical and chemical properties are crucial for quality control and application in synthetic processes. The compound's stability under normal conditions, though often requiring refrigerated storage, makes it manageable for industrial applications. When looking to purchase this intermediate, discerning buyers will examine these specifications carefully to ensure compatibility with their manufacturing protocols.

Essential Role in Anticancer Drug Synthesis

The significance of (3R,4S)-3-Hydroxy-4-phenylazetidin-2-one is most pronounced in its application as a key intermediate for Paclitaxel and Docetaxel synthesis. These drugs are cornerstone treatments for numerous cancers, and their production relies on the precise stereochemistry and purity of their precursors. The beta-lactam ring structure within this intermediate is essential for building the complex molecular framework of these powerful chemotherapeutic agents. Consequently, securing a consistent supply of high-purity (3R,4S)-3-Hydroxy-4-phenylazetidin-2-one is fundamental for pharmaceutical companies aiming to meet the global demand for these treatments.

Procurement: Quality, Reliability, and Cost

Procuring (3R,4S)-3-Hydroxy-4-phenylazetidin-2-one necessitates a focus on quality and reliability. Manufacturers typically guarantee a purity of 98% or higher, with common assays around 99%. It is vital for buyers to work with suppliers who provide comprehensive documentation, including Certificates of Analysis (COA), to verify product quality and consistency. From a cost perspective, sourcing from established manufacturers in China, like NINGBO INNO PHARMCHEM CO.,LTD., offers distinct advantages. We are committed to providing competitive pricing without compromising on quality, ensuring a reliable and cost-effective supply for your pharmaceutical needs. Whether you require gram-scale quantities for R&D or multi-kilogram batches for production, our capabilities are designed to meet your demands.

Innovative Potential in Medicinal Chemistry

Beyond its established applications, the unique structural attributes of (3R,4S)-3-Hydroxy-4-phenylazetidin-2-one also present opportunities for innovation in medicinal chemistry. Its beta-lactam core is a known pharmacophore, suggesting potential for the development of novel therapeutic agents, including new anticancer drugs or antibiotics. Researchers exploring new drug targets and mechanisms may find this intermediate a valuable starting point for their synthetic endeavors.

For organizations needing to buy or order (3R,4S)-3-Hydroxy-4-phenylazetidin-2-one, partnering with a reputable manufacturer like NINGBO INNO PHARMCHEM CO.,LTD. ensures access to a high-quality, reliable, and cost-effective intermediate that is critical for the production of essential anticancer therapies and for driving future pharmaceutical innovation.