In the pharmaceutical industry, the precise synthesis of active pharmaceutical ingredients (APIs) relies on a consistent supply of high-quality intermediates. (3R,4S)-3-Hydroxy-4-phenylazetidin-2-one, identified by CAS number 132127-34-5, is a prime example of such a critical component, playing an indispensable role in the production of widely used anticancer drugs like Paclitaxel and its derivative, Docetaxel. Understanding its properties and how to source it effectively is vital for manufacturers and researchers.

Chemical and Physical Characteristics for Synthesis

(3R,4S)-3-Hydroxy-4-phenylazetidin-2-one is a chiral molecule with the molecular formula C9H9NO2 and a molecular weight of approximately 163.17. It typically presents as a white solid with a melting point in the range of 187-188°C, signifying its stability. Key physical properties, such as a density of 1.308 and a refractive index of 1.612, are important for characterization and quality control. Manufacturers emphasize its high purity, often exceeding 98% as verified by High-Performance Liquid Chromatography (HPLC). These precise specifications are crucial for ensuring the efficacy and safety of the final pharmaceutical products derived from it. For procurement managers, detailed product specifications from a reputable manufacturer are essential when requesting quotes and placing orders.

The Crucial Role in Anticancer Drug Production

The primary application of (3R,4S)-3-Hydroxy-4-phenylazetidin-2-one is as a key intermediate in the synthesis of Paclitaxel and Docetaxel. Paclitaxel, a powerful antineoplastic agent, is synthesized using this intermediate to attach the essential side chain to the baccatin III core. Similarly, Docetaxel’s synthesis relies on this compound. The effectiveness and availability of these vital cancer treatments are directly dependent on the consistent supply of high-purity intermediates like (3R,4S)-3-Hydroxy-4-phenylazetidin-2-one. Therefore, identifying reliable manufacturers, particularly those in China renowned for their chemical synthesis expertise, is a critical step for pharmaceutical companies.

Reliable Sourcing and Quality Assurance

When seeking to purchase (3R,4S)-3-Hydroxy-4-phenylazetidin-2-one, pharmaceutical manufacturers prioritize suppliers who guarantee consistent quality and purity. Companies like NINGBO INNO PHARMCHEM CO.,LTD. are dedicated to meeting these demands. We provide products that undergo rigorous quality control measures, ensuring that each batch meets stringent industry standards. Our commitment extends to offering competitive pricing for bulk orders, making us a cost-effective choice for your manufacturing needs. We understand the importance of a stable supply chain and strive to be a trusted partner for our clients worldwide. When you need to order this vital pharmaceutical intermediate, consider our capabilities and commitment to excellence.

Innovation and Future Prospects

The unique beta-lactam structure of (3R,4S)-3-Hydroxy-4-phenylazetidin-2-one also offers potential for innovation in medicinal chemistry beyond its current primary applications. Researchers may find this compound a valuable building block for developing novel therapeutic agents or exploring new synthetic pathways. Its established role in synthesizing effective anticancer drugs positions it as a compound of continued interest for pharmaceutical R&D.

For pharmaceutical manufacturers and researchers looking to buy (3R,4S)-3-Hydroxy-4-phenylazetidin-2-one, partnering with a reliable supplier like NINGBO INNO PHARMCHEM CO.,LTD. ensures access to a high-quality, consistent, and competitively priced product that is essential for the production of critical cancer therapies and for future advancements in drug development.