The pharmaceutical industry relies on a complex network of specialized chemicals to bring life-saving treatments to market. Among these essential components is Ethyl 5-Amino-1-(2-fluorobenzyl)-1H-pyrazole-3-carboxylate, identified by its CAS number 256504-39-9. This compound is critically important as a precursor in the synthesis of Riociguat, a medication used to treat pulmonary hypertension, making it a high-demand intermediate for pharmaceutical manufacturers.

Chemical Profile and Application Significance

Ethyl 5-Amino-1-(2-fluorobenzyl)-1H-pyrazole-3-carboxylate (C13H14FN3O2, MW: 263.27) is typically supplied as an off-white to yellow solid, with purity levels of 98.0% or higher being the industry standard for pharmaceutical applications. This rigorous purity requirement is essential to ensure the integrity and efficacy of the final drug product. The compound’s structure is precisely engineered to facilitate its role in the multi-step synthesis of Riociguat, a stimulator of soluble guanylate cyclase (sGC) that helps improve blood circulation in the lungs.

The consistent supply of this intermediate directly impacts the manufacturing efficiency and output of Riociguat. Therefore, pharmaceutical companies must establish robust sourcing strategies to ensure they can procure sufficient quantities of high-quality Ethyl 5-Amino-1-(2-fluorobenzyl)-1H-pyrazole-3-carboxylate without disruption.

Strategic Sourcing and Purchase Advice

For companies looking to buy Ethyl 5-Amino-1-(2-fluorobenzyl)-1H-pyrazole-3-carboxylate, particularly in bulk for commercial production, China offers a wealth of reliable manufacturers. Key considerations when selecting a supplier include:

  • Supplier Accreditation: Verify that the manufacturer has a strong reputation and adheres to international quality standards relevant to pharmaceutical intermediates.
  • Quality Documentation: Ensure Certificates of Analysis (CoA) are readily available and demonstrate the ≥98.0% purity and other critical specifications.
  • Production Capacity and Scalability: Confirm the supplier can meet your current and future volume needs, from R&D quantities to large commercial batches.
  • Pricing and Value: Obtain multiple quotes to compare pricing. Factors such as order volume, purity, and payment terms will influence the final cost.
  • Logistical Efficiency: Assess the supplier's ability to manage international shipping and ensure timely deliveries to avoid impacting your production schedules.

Engaging directly with manufacturers, especially those based in established chemical production regions like China, often provides the best access to competitive pricing and technical support. Requesting samples for initial evaluation is a prudent step in the procurement process.

Conclusion

Ethyl 5-Amino-1-(2-fluorobenzyl)-1H-pyrazole-3-carboxylate is an indispensable intermediate for the pharmaceutical sector, specifically for the synthesis of Riociguat. By carefully selecting suppliers and prioritizing quality and supply chain reliability, pharmaceutical manufacturers can secure a steady source of this vital chemical, ensuring the continued availability of important treatments for patients worldwide. For your procurement needs, reach out to trusted manufacturers for quotes and detailed product information.