In the complex world of pharmaceutical manufacturing, the efficiency and purity of chemical intermediates are paramount. (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine, identified by CAS numbers 130018-88-1 and 300543-56-0, stands out as a crucial building block, particularly for the synthesis of levocetirizine. Levocetirizine, a highly effective antihistamine, owes its therapeutic prowess to the precise molecular structure and chirality of its precursors, making this piperazine derivative a cornerstone in its production chain.

The Chemical Profile and Importance of (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine

This intermediate is characterized as an off-white solid, a testament to the rigorous purification processes undertaken by quality manufacturers. Its molecular formula, C17H19ClN2, and a molecular weight of approximately 286.80 g/mol, provide the foundational structure for levocetirizine. The high purity, typically ≥98.0%, is critical for pharmaceutical applications, as even minor impurities can affect the final API’s efficacy, safety, and regulatory compliance. The compound’s stability and reactivity are carefully balanced to facilitate efficient synthetic transformations, a key consideration for any firm looking to buy (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine.

The chiral nature of this intermediate is of utmost importance. Levocetirizine is the R-enantiomer of cetirizine, and the stereochemical integrity must be maintained throughout the synthesis. Therefore, sourcing from a reliable (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine manufacturer who specializes in chiral synthesis is non-negotiable for pharmaceutical companies. This ensures that the resulting drug product is the intended, active enantiomer, providing targeted relief with minimal side effects.

Sourcing Strategies: Quality and Value from Global Suppliers

The global market for pharmaceutical intermediates is vast, with numerous suppliers offering a wide range of products. For critical materials like (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine, selecting the right levocetirizine intermediate supplier is a strategic decision. Companies often look to manufacturers in China due to their advanced production capabilities, economies of scale, and competitive pricing structures. When evaluating a CAS 300543-56-0 supplier, factors such as batch-to-batch consistency, adherence to quality management systems, and prompt delivery are crucial.

The price of chlorobenzhydryl piperazine is a significant consideration for manufacturers aiming to optimize their production costs. However, this must be balanced with quality assurance. A reputable supplier will provide detailed technical data sheets and certificates of analysis, confirming the purity and specifications of the product. The ability to purchase pharmaceutical intermediate reliably and at a competitive rate ensures the smooth operation of the entire production process, from raw material procurement to final API output.

Ensuring a Robust Supply Chain for Levocetirizine

The consistent availability of (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine is vital for pharmaceutical companies manufacturing levocetirizine. Disruptions in the supply chain can lead to significant production delays and financial losses. Therefore, establishing strong relationships with dependable suppliers is key. Companies that order (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine from experienced manufacturers benefit from their expertise in logistics, regulatory compliance, and risk management.

In conclusion, (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine is more than just a chemical compound; it is a critical enabler of modern allergy treatments. Its high purity, specific chirality, and reliable supply are foundational to the successful production of levocetirizine. By understanding the importance of this intermediate and by carefully selecting their suppliers, pharmaceutical companies can ensure the quality, efficacy, and availability of essential medications to patients worldwide.