Mastering Diclofenac Synthesis: The Role of 1-(2,6-Dichlorophenyl)indolin-2-one
Diclofenac, a widely used non-steroidal anti-inflammatory drug (NSAID), relies on intricate chemical processes for its synthesis. Among the key compounds involved is 1-(2,6-Dichlorophenyl)indolin-2-one, identified by its CAS number 15362-40-0. This molecule plays a dual role: it can act as a potential prodrug of Diclofenac itself, and it is also recognized as a significant impurity that can form during the commercial synthesis of Diclofenac, particularly under high-temperature conditions like autoclave sterilization.
Understanding the synthesis pathways for 1-(2,6-Dichlorophenyl)indolin-2-one is crucial for manufacturers aiming to produce high-quality Diclofenac. Various methods have been developed, ranging from classical cyclization reactions using reagents like thionyl chloride or aluminum chloride to more modern techniques such as microwave-assisted synthesis and continuous flow chemistry. These advanced methods offer advantages like reduced reaction times, improved yields, and better control over reaction parameters, contributing to more efficient and sustainable production.
The chemical properties of 1-(2,6-Dichlorophenyl)indolin-2-one are well-documented. It typically appears as an off-white to light brown solid with a specific melting point range. Its molecular formula is C14H9Cl2NO, and its molecular weight is approximately 278.13 g/mol. The compound's stability under normal conditions makes it a manageable intermediate in the complex chemical manufacturing landscape.
For pharmaceutical companies, sourcing reliable and high-purity intermediates is paramount. Companies like NINGBO INNO PHARMCHEM CO.,LTD. specialize in providing such crucial building blocks, ensuring that their products meet stringent quality standards. The availability of intermediates like 1-(2,6-Dichlorophenyl)indolin-2-one is essential for maintaining consistent production of vital medications. By understanding the importance and synthesis of such intermediates, the pharmaceutical industry can continue to develop and deliver effective treatments worldwide.
Understanding the synthesis pathways for 1-(2,6-Dichlorophenyl)indolin-2-one is crucial for manufacturers aiming to produce high-quality Diclofenac. Various methods have been developed, ranging from classical cyclization reactions using reagents like thionyl chloride or aluminum chloride to more modern techniques such as microwave-assisted synthesis and continuous flow chemistry. These advanced methods offer advantages like reduced reaction times, improved yields, and better control over reaction parameters, contributing to more efficient and sustainable production.
The chemical properties of 1-(2,6-Dichlorophenyl)indolin-2-one are well-documented. It typically appears as an off-white to light brown solid with a specific melting point range. Its molecular formula is C14H9Cl2NO, and its molecular weight is approximately 278.13 g/mol. The compound's stability under normal conditions makes it a manageable intermediate in the complex chemical manufacturing landscape.
For pharmaceutical companies, sourcing reliable and high-purity intermediates is paramount. Companies like NINGBO INNO PHARMCHEM CO.,LTD. specialize in providing such crucial building blocks, ensuring that their products meet stringent quality standards. The availability of intermediates like 1-(2,6-Dichlorophenyl)indolin-2-one is essential for maintaining consistent production of vital medications. By understanding the importance and synthesis of such intermediates, the pharmaceutical industry can continue to develop and deliver effective treatments worldwide.
Perspectives & Insights
Data Seeker X
“By understanding the importance and synthesis of such intermediates, the pharmaceutical industry can continue to develop and deliver effective treatments worldwide.”
Chem Reader AI
“Diclofenac, a widely used non-steroidal anti-inflammatory drug (NSAID), relies on intricate chemical processes for its synthesis.”
Agile Vision 2025
“Among the key compounds involved is 1-(2,6-Dichlorophenyl)indolin-2-one, identified by its CAS number 15362-40-0.”