In the intricate world of peptide synthesis, the quality and reliability of your amino acid building blocks are paramount. Among these, N-alpha-Fmoc-O-tert-butyl-L-serine, commonly known as Fmoc-Ser(tBu)-OH (CAS: 71989-33-8), stands out as a cornerstone for researchers and manufacturers employing the widely adopted Fmoc solid-phase peptide synthesis (SPPS) strategy. As a dedicated supplier and manufacturer, we understand the critical importance of this derivative and are committed to providing you with the insights and materials necessary for success.

Fmoc-Ser(tBu)-OH is a derivative of the amino acid serine, distinguished by two key features crucial for peptide synthesis: the fluorenylmethoxycarbonyl (Fmoc) group and the tert-butyl (tBu) ether protection on the serine side chain. The Fmoc group serves as a base-labile protecting group for the alpha-amino function, ensuring that peptide bond formation occurs selectively at the desired N-terminus during chain elongation. The tert-butyl group, on the other hand, protects the reactive hydroxyl group of serine, preventing unwanted side reactions during synthesis and being readily removable under standard acidic cleavage conditions used to cleave the final peptide from the resin.

For procurement professionals and research scientists looking to buy Fmoc-Ser(tBu)-OH, understanding its chemical properties is key. This compound typically appears as a white to off-white powder, with a molecular formula of C22H25NO5 and a molecular weight of approximately 383.44 g/mol. Its high purity, often exceeding 99%, is a testament to the stringent manufacturing processes employed by reputable suppliers. When you search for an Fmoc-Ser(tBu)-OH manufacturer in China, prioritize those with robust quality control systems and a proven track record.

The primary application of Fmoc-Ser(tBu)-OH is in the construction of peptide chains through SPPS. Whether you are developing novel therapeutic peptides, synthesizing peptide libraries for drug discovery, or creating custom peptides for research, this derivative ensures that serine residues are incorporated accurately and efficiently. Its acid-labile protection strategy simplifies the overall synthesis and purification process, making it a preferred choice for many laboratories and chemical synthesis companies.

When considering the Fmoc-Ser(tBu)-OH price, it’s important to evaluate not just the cost per gram but also the purity, batch consistency, and the reliability of the Fmoc-amino acid supplier. Investing in high-quality Fmoc-Ser(tBu)-OH from a trusted source not only enhances the success rate of your peptide synthesis but also avoids costly re-syntheses due to impurity-related failures. For those requiring Fmoc-Ser(tBu)-OH bulk purchase, establishing a strong relationship with a direct manufacturer can provide significant advantages in terms of pricing and supply chain stability.

As your dedicated partner in peptide synthesis, we are proud to be a leading supplier of Fmoc-amino acids and other critical reagents. We ensure that our Fmoc-Ser(tBu)-OH meets the highest standards, supporting your journey from initial research to final product development. Explore our offerings and discover the difference that quality and commitment can make in your peptide synthesis endeavors. Contact us today for competitive quotes and detailed product information.