In the realm of peptide synthesis, the choice of protected amino acid derivatives is crucial for successful and efficient synthesis of complex peptide sequences. Fmoc-Ser(tBu)-OH, or N-alpha-Fmoc-O-tert-butyl-L-serine, stands out as a fundamental reagent for researchers and manufacturers employing the Fmoc solid-phase peptide synthesis (SPPS) strategy. Its specific structure and protection scheme are vital for introducing serine residues accurately into peptide chains.

Fmoc-Ser(tBu)-OH, bearing the CAS number 71989-33-8, is a derivative of the naturally occurring amino acid L-serine. The defining features of this compound are the orthogonal protecting groups: the N-alpha-amino group is protected by the base-labile Fmoc (9-fluorenylmethoxycarbonyl) group, and the side-chain hydroxyl group is protected by the acid-labile tert-butyl (tBu) ether. This dual protection system is the backbone of the Fmoc SPPS methodology. The Fmoc group allows for repetitive cycles of deprotection using mild basic conditions (e.g., piperidine), exposing the N-terminus for subsequent amino acid coupling. The tBu group on the serine side chain protects the reactive hydroxyl from participating in unwanted side reactions during these coupling and deprotection steps. It remains intact until the final cleavage of the peptide from the resin, which is typically performed using strong acidic conditions (e.g., trifluoroacetic acid cocktails), at which point both the peptide-resin bond and side-chain protecting groups are removed.

The typical appearance of Fmoc-Ser(tBu)-OH is a white to off-white powder, with a molecular weight of approximately 383.44 g/mol. High purity, often exceeding 99%, is essential for reliable peptide synthesis. Researchers and pharmaceutical companies looking to buy Fmoc-Ser(tBu)-OH must prioritize sourcing from reputable suppliers who can guarantee lot-to-lot consistency and provide detailed analytical data such as HPLC and NMR spectra. As a leading Fmoc-amino acid supplier, we ensure our product meets these exacting standards.

The applications of Fmoc-Ser(tBu)-OH are diverse, primarily centered around the synthesis of peptides for research, drug discovery, and therapeutic development. Serine residues are common in many bioactive peptides and proteins, participating in phosphorylation, glycosylation, and hydrogen bonding interactions crucial for biological activity. The ability to cleanly incorporate serine using Fmoc-Ser(tBu)-OH is vital for creating peptides with specific structures and functions, such as peptide hormones, enzyme inhibitors, and diagnostic agents. When considering Fmoc-Ser(tBu)-OH price, it is important to factor in the overall value proposition: high purity, reliable supply from a trusted Fmoc-Ser(tBu)-OH manufacturer, and strong technical support.

For those requiring significant quantities, exploring Fmoc-Ser(tBu)-OH bulk purchase options directly from a manufacturer can offer economic advantages without compromising quality. Our commitment as a chemical synthesis company is to provide researchers and manufacturers with the highest quality peptide synthesis reagents, enabling advancements in various scientific fields. We aim to be your preferred partner for all your peptide synthesis reagent needs.