Organic synthesis is the bedrock of innovation in chemistry, enabling the creation of novel materials, pharmaceuticals, and agrochemicals. Central to this discipline is the strategic selection of versatile building blocks. Among these, 5-Fluoro-2-hydroxybenzonitrile (CAS: 91407-41-9) stands out due to its unique combination of functional groups and its fluorine substituent, which can subtly modulate molecular properties. For chemists aiming to achieve efficient and selective transformations, understanding how to effectively buy 5-Fluoro-2-hydroxybenzonitrile and utilize it is key.

The Chemistry of 5-Fluoro-2-hydroxybenzonitrile

The 5-Fluoro-2-hydroxybenzonitrile molecule presents several reactive sites, making it a highly adaptable component in synthetic strategies. The nitrile group can be hydrolyzed to a carboxylic acid or reduced to an amine, offering pathways to diverse functional groups. The phenolic hydroxyl group can be alkylated, acylated, or serve as a directing group in electrophilic aromatic substitution. Crucially, the fluorine atom often enhances metabolic stability and lipophilicity in derived molecules, properties highly sought after in drug design. This makes it an excellent pharmaceutical intermediate for creating compounds with improved pharmacokinetic profiles.

Key Synthetic Transformations to Employ

When integrating 5-Fluoro-2-hydroxybenzonitrile into a synthetic route, chemists often leverage its potential in metal-catalyzed cross-coupling reactions. For instance, palladium-catalyzed Suzuki-Miyaura coupling can be used to introduce aryl or vinyl groups at the position of a halide or triflate derived from the hydroxyl group. Alternatively, Ullmann-type couplings can forge new C-O or C-N bonds. The electron-withdrawing nature of the nitrile and fluorine groups can also activate the aromatic ring for nucleophilic aromatic substitution, allowing for the introduction of various nucleophiles. To successfully implement these advanced techniques, sourcing from a reliable 5-Fluoro-2-hydroxybenzonitrile manufacturer in China who can guarantee consistent product quality and reactivity is essential.

Optimizing Procurement for Research and Production

For procurement managers, securing a steady supply of 5-Fluoro-2-hydroxybenzonitrile at a competitive price is vital for both R&D projects and larger-scale production. Researching and comparing different CAS 91407-41-9 suppliers is a crucial step. Look for suppliers who provide detailed product information, including spectroscopic data (NMR, MS) and application examples. Furthermore, understanding the manufacturing process and quality control measures employed by a potential supplier can help mitigate risks and ensure the intermediate meets the precise requirements of your synthesis.

Conclusion

5-Fluoro-2-hydroxybenzonitrile is an indispensable tool for modern organic chemists. Its rich reactivity profile allows for the efficient construction of complex molecular scaffolds, making it a cornerstone intermediate for advancements in pharmaceuticals, agrochemicals, and materials science. By understanding its chemical properties and adopting strategic sourcing practices, chemists and procurement specialists can harness the full potential of this remarkable compound.