The pharmaceutical industry relies heavily on precisely synthesized chemical intermediates to produce life-saving and therapeutic drugs. For manufacturers of Lornoxicam, a potent NSAID, the quality and availability of its key precursor, Methyl 5-chloro-3-[(2-methoxy-2-oxoethyl)sulfamoyl]-2-thiophenecarboxylate (CAS: 906522-87-0), are critical success factors. This article highlights why this specific thiophene derivative is essential and what manufacturers should look for when seeking a reliable supplier or manufacturer for this compound.

The Role of Methyl 5-Chloro-3-Sulfamoyl-2-Thiophenecarboxylate in Lornoxicam Synthesis

Methyl 5-chloro-3-[(2-methoxy-2-oxoethyl)sulfamoyl]-2-thiophenecarboxylate serves as a foundational building block in the multi-step synthesis of Lornoxicam. Its unique chemical structure, featuring a thiophene ring substituted with chlorine and a sulfamoyl group, is strategically designed to facilitate subsequent chemical reactions that ultimately yield the final API. The efficiency of the entire synthesis process, including yield and purity of the Lornoxicam API, is intrinsically linked to the quality of this starting material. Therefore, when intending to buy this intermediate, demanding strict quality specifications is a standard practice.

Essential Specifications and Quality Assurance

For API manufacturers, the specifications of Methyl 5-chloro-3-[(2-methoxy-2-oxoethyl)sulfamoyl]-2-thiophenecarboxylate are non-negotiable. Key parameters include:

  • Appearance: Typically a yellow crystalline powder, indicating its physical state and preliminary purity assessment.
  • Assay: A high assay, such as ≥99.0% by HPLC, ensures that the material is predominantly the desired compound, minimizing the presence of other chemical entities.
  • Impurity Profile: Strict limits on single impurities (≤0.5%) and total impurities (≤1.0%) are crucial to prevent downstream contamination and ensure compliance with pharmacopeial standards.
  • Loss on Drying: A low loss on drying (≤0.5%) indicates minimal moisture content, which is important for stability and accurate weighing during reactions.

Partnering with a manufacturer that can consistently meet these specifications is vital for uninterrupted API production.

Choosing the Right Manufacturer/Supplier

When sourcing chemical intermediates, particularly for pharmaceutical applications, selecting the right manufacturer is as important as the quality of the chemical itself. Companies looking to purchase Methyl 5-chloro-3-[(2-methoxy-2-oxoethyl)sulfamoyl]-2-thiophenecarboxylate should seek suppliers who:

  • Have a proven track record in producing pharmaceutical intermediates.
  • Offer competitive pricing, especially for bulk quantities.
  • Provide comprehensive documentation, including Certificates of Analysis (CoA) and Material Safety Data Sheets (MSDS).
  • Have robust quality management systems in place.
  • Can guarantee a stable supply chain and timely delivery.

By focusing on these aspects, pharmaceutical manufacturers can secure a dependable source of this critical intermediate, thereby optimizing their Lornoxicam API production and ensuring the consistent quality of their final pharmaceutical product. We are a dedicated supplier ready to meet your requirements.