The journey of a pharmaceutical product from lab to market involves numerous complex steps, with the procurement of high-quality intermediates being a critical one. Methyl 5-formyl-2-methoxybenzoate (CAS 78515-16-9) is a vital intermediate, predominantly used in the synthesis of Eluxadoline. Understanding its synthesis and how to efficiently source it is essential for pharmaceutical manufacturers and R&D teams.

Synthesis of Methyl 5-formyl-2-methoxybenzoate

The chemical synthesis of Methyl 5-formyl-2-methoxybenzoate typically involves established organic chemistry reactions. A common pathway described in literature starts from a precursor like 5-formyl-2-hydroxybenzoic acid. This precursor is then reacted with iodomethane in the presence of a base, such as potassium carbonate, in a suitable solvent like dimethylformamide (DMF). The reaction methylates the hydroxyl group, yielding the target compound. Following the reaction, purification steps like extraction, drying, and column chromatography are employed to achieve the desired purity.

Key reactants in this synthesis often include:

  • 5-Formyl-2-hydroxybenzoic acid
  • Iodomethane (or other methylating agents)
  • Potassium Carbonate (as a base)
  • Dimethylformamide (as a solvent)

The yield and purity achieved depend on precise control of reaction conditions, stoichiometry, and purification techniques. Manufacturers specializing in fine chemicals and pharmaceutical intermediates invest heavily in optimizing these processes.

Strategic Sourcing for Pharmaceutical Use

For companies looking to buy methyl 5-formyl-2-methoxybenzoate, strategic sourcing is key. Identifying a reliable manufacturer or supplier is paramount to ensure consistent quality and timely delivery, especially when scaling up production. Factors to consider include:

  • Purity and Assay: Confirm that the product meets the required pharmaceutical grade specifications (e.g., ≥97.0% purity).
  • Manufacturing Expertise: Partner with companies that have demonstrated expertise in complex organic synthesis and pharmaceutical intermediate production. NINGBO INNO PHARMCHEM CO.,LTD. is a recognized leader in this field.
  • Global Reach and Logistics: A supplier with efficient global logistics can ensure prompt delivery to your location, minimizing supply chain disruptions.
  • Competitive Pricing: While quality is the priority, obtaining competitive price information is essential for cost management. Suppliers in China often offer advantageous pricing structures.
  • Documentation: Ensure that comprehensive documentation such as Certificates of Analysis (CoA) and Material Safety Data Sheets (MSDS) are readily available.

By understanding the synthesis routes and focusing on strategic sourcing from reputable partners, pharmaceutical companies can secure a reliable supply of Methyl 5-formyl-2-methoxybenzoate, facilitating the efficient development and production of vital medications. We encourage you to reach out to experienced manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. for your procurement needs.