In the dynamic field of organic synthesis, the availability of versatile and high-purity building blocks is crucial for innovation and efficiency. Methyl 6-Bromopicolinate, identified by its CAS number 26218-75-7, is one such indispensable compound. Its unique molecular structure, featuring a brominated pyridine ring with a methyl ester functional group, lends itself to a wide array of chemical transformations. This makes it a sought-after intermediate for researchers and chemists engaged in developing novel organic compounds, including pharmaceuticals, agrochemicals, and specialty materials. If you are looking to buy Methyl 6-Bromopicolinate, understanding its chemical characteristics and supplier landscape is key.

Chemical Properties and Reactivity

Methyl 6-Bromopicolinate (C7H6BrNO2) possesses a molecular weight of 216.03. The bromine atom at the 6-position of the pyridine ring is susceptible to nucleophilic aromatic substitution and various metal-catalyzed coupling reactions, such as Suzuki, Stille, and Sonogashira couplings. These reactions allow for the introduction of diverse substituents onto the pyridine core, creating complex molecular frameworks. The methyl ester group at the 2-position can be readily hydrolyzed to the corresponding carboxylic acid or converted into other ester derivatives or amides, further expanding its synthetic utility. The compound typically appears as a white powder, with a purity often exceeding 99%, which is vital for sensitive organic synthesis.

Applications in Organic Synthesis

The versatility of Methyl 6-Bromopicolinate translates into its widespread application:

  • Pharmaceutical Intermediates: It serves as a pivotal precursor in the synthesis of numerous drug candidates and approved pharmaceuticals. Its pyridine scaffold is a common motif in many biologically active molecules. Researchers often search for suppliers of this compound when developing new cancer therapies, antivirals, or central nervous system agents.
  • Agrochemicals: The pyridine ring system is also prevalent in many herbicides and insecticides. Methyl 6-Bromopicolinate can be employed as a starting material for creating novel agrochemical compounds with enhanced efficacy and targeted action.
  • Materials Science: In materials science, pyridine derivatives are utilized in the development of functional materials, such as organic light-emitting diodes (OLEDs) and coordination polymers. Methyl 6-Bromopicolinate can act as a building block for these advanced materials.
  • Research and Development: Academic and industrial research laboratories frequently use it for exploring new synthetic methodologies and discovering novel chemical entities.

Where to Purchase Methyl 6-Bromopicolinate

For those seeking to purchase Methyl 6-Bromopicolinate, especially in bulk quantities or with specific purity requirements, sourcing from reputable chemical manufacturers and suppliers is essential. Leading chemical suppliers based in China are known for offering this intermediate at competitive prices. When you need to buy Methyl 6-Bromopicolinate, it's advisable to:

  1. Identify Reliable Suppliers: Look for companies with a proven track record in producing and supplying fine chemicals and pharmaceutical intermediates.
  2. Verify Purity and Specifications: Always request a Certificate of Analysis (CoA) to confirm the product's purity (e.g., ≥99%) and ensure it matches your needs.
  3. Compare Prices and MOQs: Obtain quotes from multiple vendors to secure the best possible price and understand their minimum order quantities.
  4. Consider Packaging and Shipping: Ensure the supplier offers appropriate packaging for safe transport and inquire about shipping options and associated costs.

By leveraging these strategies, scientists and chemists can efficiently acquire Methyl 6-Bromopicolinate for their critical synthesis projects, driving innovation in their respective fields.