Mitochondria are central to cellular life, not only as the primary sites of ATP production but also as key regulators of cellular metabolism and signaling pathways. Their health and function are intrinsically linked to overall cellular well-being and are implicated in aging and numerous chronic diseases. The enzyme SIRT3, a mitochondrial sirtuin, plays a critical role in maintaining mitochondrial homeostasis through deacetylation of various mitochondrial proteins. Consequently, understanding and modulating SIRT3 activity is a growing area of interest in biological research. 3-TYP (CAS 120241-79-4), a selective SIRT3 inhibitor, offers researchers a precise tool to explore these vital processes. NINGBO INNO PHARMCHEM CO.,LTD., a prominent manufacturer and supplier based in China, provides high-purity 3-TYP to support these investigations.

The Central Role of SIRT3 in Mitochondria

SIRT3's influence extends across multiple facets of mitochondrial function. It regulates enzymes involved in the Krebs cycle and oxidative phosphorylation, thereby controlling energy production. Furthermore, SIRT3 is a key player in antioxidant defense, deacetylating enzymes like MnSOD (SOD2), which directly neutralizes superoxide radicals. By controlling these critical functions, SIRT3 acts as a guardian of mitochondrial health. Researchers aiming to unravel the complexities of mitochondrial disorders, metabolic diseases, or aging often need to modulate SIRT3 activity, making the purchase of a reliable inhibitor like 3-TYP a strategic necessity.

3-TYP: Precision Tool for Mitochondrial Research

The distinguishing feature of 3-TYP is its high selectivity for SIRT3 over other sirtuins. With an IC50 of 16 nM for SIRT3, compared to 88 nM for SIRT1 and 92 nM for SIRT2, 3-TYP allows researchers to isolate and study the specific effects of SIRT3 inhibition. This precision is invaluable when investigating the complex mitochondrial environment. For example, studying the impact of SIRT3 inhibition on cellular respiration, ROS production, or the acetylation status of key mitochondrial proteins can be more accurately performed using a selective inhibitor. This makes buying 3-TYP from a reputable supplier a crucial step for reliable scientific outcomes.

Why Choose NINGBO INNO PHARMCHEM as Your 3-TYP Manufacturer?

NINGBO INNO PHARMCHEM CO.,LTD. prides itself on being a leading manufacturer and supplier of high-quality research chemicals, including 3-TYP, from China. We understand the critical importance of purity and consistency for research reagents. Our state-of-the-art manufacturing facilities and rigorous quality control protocols ensure that every batch of 3-TYP meets exacting standards. As a direct manufacturer, we offer competitive pricing for bulk purchases, making advanced research more accessible. We are committed to fostering scientific progress by providing reliable access to essential compounds. Whether you require small research quantities or larger industrial volumes, our supply chain is robust and dependable.

Applications of 3-TYP in Mitochondrial Studies

Researchers utilize 3-TYP for a variety of critical investigations, including:

  • Investigating the role of SIRT3 in regulating ATP synthesis and cellular energy metabolism.
  • Studying the impact of SIRT3 inhibition on mitochondrial antioxidant defense systems.
  • Exploring the connection between SIRT3 activity and age-related mitochondrial decline.
  • Developing therapeutic strategies targeting mitochondrial dysfunction in various diseases.

If your research demands a reliable and selective SIRT3 inhibitor, consider NINGBO INNO PHARMCHEM as your trusted source for 3-TYP. We offer competitive pricing and a commitment to quality, making us an ideal partner for your laboratory needs. Contact us today for a quote and to discuss your requirements for this essential pharmaceutical intermediate.