In the dynamic field of molecular biology and pharmaceutical research, understanding and modulating specific protein activities is paramount. Among the sirtuin family, SIRT3 stands out for its crucial role in mitochondrial function, cellular metabolism, and protection against oxidative stress. For researchers aiming to delve into these areas, acquiring a potent and selective SIRT3 inhibitor is essential. This is where 3-TYP (CAS 120241-79-4) emerges as a critical research chemical and pharmaceutical intermediate.

Why is SIRT3 Inhibition Important?

SIRT3, a NAD+-dependent deacetylase primarily located in mitochondria, plays a significant role in regulating cellular energy homeostasis and mitigating damage caused by reactive oxygen species (ROS). Its activity is linked to various physiological processes, including ATP production, antioxidant defense, and apoptosis. Dysregulation of SIRT3 has been implicated in a range of conditions, from metabolic disorders and cardiovascular diseases to neurodegenerative disorders and cancer. Therefore, selectively inhibiting SIRT3 provides a powerful tool to explore these pathways and develop potential therapeutic interventions. This makes the purchase of reliable 3-TYP a strategic move for any research institution or pharmaceutical company.

Understanding 3-TYP: Selectivity and Potency

3-TYP is recognized for its high selectivity and potency as a SIRT3 inhibitor. Scientific literature consistently reports its IC50 value for SIRT3 to be around 16 nM, while its inhibitory effect on SIRT1 and SIRT2 is considerably weaker, with IC50 values around 88 nM and 92 nM, respectively. This remarkable selectivity ensures that researchers can focus on the specific effects mediated by SIRT3 inhibition, minimizing potential confounding results from off-target interactions. For any serious buyer looking for accurate research outcomes, this level of specificity is a non-negotiable feature when considering a 3-TYP supplier.

Sourcing High-Quality 3-TYP from China

When it comes to purchasing critical research chemicals like 3-TYP, quality and reliability are paramount. NINGBO INNO PHARMCHEM CO.,LTD. stands as a leading manufacturer and supplier of high-purity 3-TYP based in China. We understand the stringent requirements of pharmaceutical research and development. Our commitment is to provide scientists with a dependable source for their 3-TYP needs, ensuring product integrity and consistency. We offer competitive pricing for our 3-TYP, making it accessible for both academic research and industrial applications. If you are looking to buy 3-TYP for your next project, consider the advantages of sourcing from a reputable manufacturer known for its quality and customer service. We are ready to provide you with a quote for your purchase, and we also offer free samples to qualified buyers.

Applications in Research and Development

The applications of 3-TYP as a selective SIRT3 inhibitor are vast and continue to expand. Researchers utilize it to:

  • Investigate the role of SIRT3 in mitochondrial respiration and energy metabolism.
  • Study the mechanisms of oxidative stress and develop antioxidant strategies.
  • Explore SIRT3's involvement in aging processes and age-related diseases.
  • Evaluate potential therapeutic targets for metabolic syndrome, cardiovascular disease, and neurodegenerative disorders.
  • Serve as a key pharmaceutical intermediate in the synthesis of novel drug candidates.

By choosing NINGBO INNO PHARMCHEM CO.,LTD. as your manufacturer and supplier, you ensure that your research is backed by premium-grade 3-TYP. We are dedicated to supporting scientific advancement through the provision of high-quality chemical products. Reach out to us today to learn more about our 3-TYP offerings and to discuss your specific purchasing requirements.