The pharmaceutical industry constantly seeks novel compounds and efficient synthesis routes to develop life-saving medications. Intermediates play a pivotal role in this process, and N-(Benzyloxycarbonyl)-DL-tert-Leucine Methyl Ester (CAS 141971-09-7) has emerged as a valuable tool for researchers. Its unique chemical structure and properties make it indispensable in various stages of drug discovery and development.

Understanding the Chemical Profile

N-(Benzyloxycarbonyl)-DL-tert-Leucine Methyl Ester, often abbreviated or referred to by synonyms like N-CBZ-3-METHYL-DL-VALINE METHYL ESTER, is a protected amino acid derivative. Its molecular formula is C15H21NO4. The presence of the CBZ protecting group on the amino nitrogen and the methyl ester on the carboxyl group offers strategic advantages in synthetic chemistry. The tert-leucine backbone itself, with its bulky tert-butyl side chain, imparts specific conformational constraints and lipophilicity, which can be beneficial in designing drug molecules that interact effectively with biological targets.

Key Applications in Pharmaceutical Research

The utility of N-(Benzyloxycarbonyl)-DL-tert-Leucine Methyl Ester spans several critical areas of pharmaceutical research:

  • Peptidomimetics and Peptide Drugs: This intermediate is instrumental in the synthesis of peptidomimetics – compounds that mimic the biological activity of peptides but often have improved stability, oral bioavailability, or reduced immunogenicity. Researchers utilize it to incorporate non-natural amino acid residues into peptide chains.
  • Small Molecule Synthesis: Beyond peptides, it serves as a versatile chiral building block for the synthesis of complex small molecule drugs. Its defined stereochemistry (DL form implies a racemic mixture or a specific enantiomer might be further separated or synthesized) allows for precise control over the three-dimensional structure of the final API.
  • Drug Candidate Optimization: In lead optimization phases, medicinal chemists often modify existing drug candidates to enhance their pharmacokinetic and pharmacodynamic properties. N-(Benzyloxycarbonyl)-DL-tert-Leucine Methyl Ester can be employed to introduce structural variations that might improve target binding affinity, metabolic stability, or reduce off-target effects.
  • Process Development: For manufacturers, understanding the reliable supply of CAS 141971-09-7 from trusted suppliers is key to developing robust and scalable manufacturing processes for new drugs.

Sourcing and Quality Assurance

When sourcing this important intermediate, it is vital to partner with reputable manufacturers and suppliers. A chemical supplier that provides detailed technical data, consistent quality, and competitive pricing for N-(Benzyloxycarbonyl)-DL-tert-Leucine Methyl Ester ensures that research projects can proceed without interruption. Always inquire about purity, batch-to-batch consistency, and the supplier's commitment to quality standards.

In summary, N-(Benzyloxycarbonyl)-DL-tert-Leucine Methyl Ester is a cornerstone intermediate for pharmaceutical researchers and developers. Its unique structural features enable the creation of novel therapeutics, driving innovation in drug discovery. Ensuring a reliable supply from a quality manufacturer is the first step for any research team looking to leverage this versatile chemical.