N-Carbobenzyloxyglycine: A Versatile Building Block for Organic Synthesis
Organic synthesis is the art and science of constructing complex molecules from simpler ones, a field where versatile building blocks are indispensable. N-Carbobenzyloxyglycine, known by its CAS number 1138-80-3 and often abbreviated as Z-Gly-OH, stands out as a prime example of such a crucial component. This protected amino acid derivative is widely employed for its predictable reactivity and its ability to introduce the glycine moiety into target molecules with precision.
The compound presents as a white crystalline powder, a form that is conducive to handling and precise measurement in laboratory settings. Its chemical structure, C10H11NO4, with a molecular weight of approximately 209.2 g/mol, has been carefully designed to serve as an efficient building block. The benzyloxycarbonyl (Cbz) protecting group on the nitrogen atom is key to its utility in organic synthesis. It shields the amino group from participating in unwanted reactions while allowing the carboxyl group to undergo esterification, amidation, or other necessary transformations. This selective protection makes N-Carbobenzyloxyglycine a preferred choice for chemists seeking to control reaction pathways.
Beyond its role in peptide synthesis, N-Carbobenzyloxyglycine serves as a versatile intermediate in the broader landscape of organic synthesis. It can be utilized in the creation of heterocyclic compounds, chiral auxiliaries, and various specialty chemicals. The ability to easily remove the Cbz group under mild deprotection conditions (e.g., catalytic hydrogenation) adds to its synthetic flexibility. Therefore, when researchers decide to buy N-Carbobenzyloxyglycine online, they are acquiring a foundational element for constructing a wide array of organic structures.
The global availability of this CAS 1138-80-3 chemical intermediate, often sourced from manufacturers in China, ensures that academic and industrial researchers have consistent access to this vital reagent. Its purity and quality are paramount, directly influencing the efficiency and outcome of complex synthetic routes, making it an enduringly valuable tool in the organic chemist's arsenal.
Perspectives & Insights
Agile Reader One
“It shields the amino group from participating in unwanted reactions while allowing the carboxyl group to undergo esterification, amidation, or other necessary transformations.”
Logic Vision Labs
“This selective protection makes N-Carbobenzyloxyglycine a preferred choice for chemists seeking to control reaction pathways.”
Molecule Origin 88
“Beyond its role in peptide synthesis, N-Carbobenzyloxyglycine serves as a versatile intermediate in the broader landscape of organic synthesis.”