The field of medicinal chemistry is constantly seeking novel compounds to address unmet medical needs. Within this pursuit, specific chemical intermediates play indispensable roles, enabling the synthesis of complex drug candidates. N,N'-Di-Boc-thiourea, identified by CAS number 145013-05-4, is one such critical intermediate, particularly recognized for its utility in the research of α1-adrenoceptor antagonists.

Alpha-1 (α1) adrenoceptors are a class of G protein-coupled receptors found throughout the body, including in smooth muscle tissue and the central nervous system. Antagonists targeting these receptors have found significant therapeutic applications, most notably in the treatment of hypertension (high blood pressure) and benign prostatic hyperplasia (BPH). The development of selective and effective α1-adrenoceptor antagonists often relies on sophisticated synthetic routes, where precisely designed building blocks are essential.

N,N'-Di-Boc-thiourea serves as a key precursor in the synthesis of bis-imidazoline diphenyl derivatives. These derivatives are a well-established structural class of α1-adrenoceptor antagonists. The presence of the two tert-butoxycarbonyl (Boc) protecting groups on the thiourea nitrogen atoms is crucial. These groups allow for controlled chemical transformations, guiding the synthesis towards the desired bis-imidazoline ring structure while preventing unwanted side reactions. The compound's high purity, typically ≥98%, ensures the efficiency and success of these complex synthetic steps, vital for drug discovery research.

For researchers and pharmaceutical companies engaged in the development of α1-adrenoceptor antagonists, securing a reliable supply of high-quality N,N'-Di-Boc-thiourea is paramount. NINGBO INNO PHARMCHEM CO.,LTD. functions as a dedicated manufacturer and supplier, offering this essential intermediate. Our commitment to quality ensures that researchers can confidently buy N,N'-Di-Boc-thiourea for their projects, knowing they are working with a dependable raw material. The availability of this compound from trusted sources in China, such as ourselves, facilitates more accessible and potentially cost-effective research and development.

The chemical structure of N,N'-Di-Boc-thiourea, being a protected form of thiourea, allows chemists to strategically introduce it into larger molecular frameworks. Its white powder appearance and specific storage requirements (0-5°C) are standard parameters that researchers rely on from a reputable supplier. By providing this intermediate, we enable advancements in the discovery and optimization of new pharmaceutical agents targeting α1-adrenoceptors, contributing to the development of improved treatments for various medical conditions.

In summary, N,N'-Di-Boc-thiourea is a pivotal intermediate that empowers the research and synthesis of α1-adrenoceptor antagonists. Its protected structure and high purity make it an invaluable tool for medicinal chemists. As a reliable manufacturer and supplier, we are dedicated to providing this critical compound to support ongoing advancements in pharmaceutical research.