In the realm of fine chemicals and pharmaceutical synthesis, N,N'-Di-Boc-thiourea stands out as a compound of significant utility. With its chemical name tert-butyl N-[(2-methylpropan-2-yl)oxycarbonylcarbamothioyl]carbamate and CAS number 145013-05-4, this molecule, often simply referred to as N,N'-Di-Boc-thiourea, is a critical building block. Its importance is underscored by its role in creating complex derivatives vital for medicinal chemistry. As a leading supplier of such intermediates, understanding its synthesis and applications is key for any professional in the field.

The synthesis of N,N'-Di-Boc-thiourea typically involves the reaction of thiourea with di-tert-butyl dicarbonate (Boc anhydride). This process introduces the tert-butoxycarbonyl (Boc) protecting groups onto the nitrogen atoms of the thiourea molecule. The Boc groups serve to deactivate the nitrogen atoms, preventing unwanted side reactions and allowing for controlled functionalization elsewhere in the molecule or in subsequent reaction steps. The result is a white powder with a high purity, often exceeding 98%, making it an ideal raw material for demanding applications.

The primary application driving the demand for N,N'-Di-Boc-thiourea is its use in the preparation of bis-imidazoline diphenyl derivatives. These derivatives are recognized for their potent activity as α1-adrenoceptor antagonists. Such antagonists are crucial in the pharmaceutical industry for the development of drugs treating conditions like hypertension and benign prostatic hyperplasia. The specific structure and protection offered by N,N'-Di-Boc-thiourea are instrumental in the efficient and selective synthesis of these active pharmaceutical ingredients (APIs).

For pharmaceutical manufacturers and researchers, sourcing reliable N,N'-Di-Boc-thiourea is essential. As a dedicated manufacturer and supplier, NINGBO INNO PHARMCHEM CO.,LTD. provides this key intermediate with consistent quality and competitive pricing. Whether you are looking to buy for research purposes or for large-scale production, our commitment ensures you receive a product that meets stringent specifications. The physical properties, such as its solid state (white powder) and specific melting point, are indicators of its quality. Proper storage, typically at 0-5°C, is recommended to maintain its integrity.

In conclusion, N,N'-Di-Boc-thiourea is more than just a chemical reagent; it's a gateway to developing advanced therapeutics. Its carefully protected structure enables precise chemical transformations, making it an indispensable component in the synthesis of vital pharmaceuticals. For any entity looking to purchase this essential intermediate, ensuring a high-purity, reliably sourced product from a trusted manufacturer is the first step towards successful drug development.