The global chemical market is dynamic, with pricing for raw materials and intermediates subject to various influencing factors. For procurement professionals and research scientists, understanding these dynamics is key to making informed purchasing decisions. This article delves into the pricing considerations for pharmaceutical intermediates, using (S)-1-(4-Phenyl-1H-imidazol-2-yl)ethanamine (CAS 864825-23-0) as a case study.

Factors Affecting Intermediate Pricing

When a buyer searches for the CAS 864825-23-0 price, several elements contribute to the final figure provided by a manufacturer or supplier:

  1. Raw Material Costs: The price of the precursor chemicals used in the synthesis of (S)-1-(4-Phenyl-1H-imidazol-2-yl)ethanamine directly impacts its production cost. Fluctuations in the availability and cost of these raw materials can lead to price variations.
  2. Manufacturing Complexity: The synthesis of chiral intermediates often involves multi-step processes, specialized equipment, and rigorous quality control measures. The complexity of producing enantiomerically pure compounds like this imidazole derivative contributes to its price.
  3. Purity and Assay: Higher purity levels and precise assay requirements, such as the ≥99.0% commonly sought for this compound, necessitate more stringent purification steps, thereby increasing production costs and, consequently, the selling price.
  4. Scale of Production: Economies of scale play a significant role. Larger production batches generally lead to lower per-unit costs due to more efficient utilization of resources and overhead. Therefore, bulk purchase inquiries for intermediates often yield better pricing.
  5. Research and Development Investment: Manufacturers invest heavily in process development and analytical method validation. These R&D costs are factored into the pricing structure.
  6. Market Demand and Supply: As with any commodity, the interplay of market demand for Eluxadoline and its precursors, and the available supply from manufacturers, influences pricing.

Strategies for Cost-Effective Sourcing

To secure competitive pricing when looking to buy (S)-1-(4-Phenyl-1H-imidazol-2-yl)ethanamine, consider these strategies:

  • Obtain Multiple Quotes: Contact several reputable manufacturers and suppliers, particularly those operating as an (S)-1-(4-Phenyl-1H-imidazol-2-yl)ethanamine manufacturer from regions known for competitive chemical production, like China.
  • Forecast Your Needs: Providing a clear forecast of your annual or quarterly requirements allows suppliers to better plan production and potentially offer more favorable pricing for larger commitments.
  • Consider Pack Sizes: Suppliers often have tiered pricing based on pack sizes. Smaller quantities for R&D will typically be more expensive per gram than larger drums for commercial production.
  • Long-Term Supply Agreements: For ongoing projects, establishing long-term supply agreements can lock in prices and ensure supply continuity.

Understanding the underlying cost drivers allows procurement professionals to negotiate effectively with suppliers and ensure they are receiving optimal value. When sourcing critical pharmaceutical intermediates, balancing price with unwavering quality and supply reliability is paramount for successful drug development.