The global chemical market is dynamic, with a constant demand for specialized intermediates driven by advancements in pharmaceuticals, materials science, and research. For those in the pharmaceutical industry, sourcing specific compounds like 7-Chloro-1,2,3,4-Tetrahydrobenzo[b]azepin-5-one (CAS: 160129-45-3) requires a strategic approach. This article provides insights into navigating the market to effectively purchase this crucial chemical.

Understanding the Compound's Significance

7-Chloro-1,2,3,4-Tetrahydrobenzo[b]azepin-5-one is recognized primarily as a key intermediate in the synthesis of pharmaceutical products, most notably Tolvaptan. Its molecular structure (C10H10ClNO, MW: 195.65) makes it an invaluable building block for creating complex APIs. The demand for this compound is directly linked to the production needs of the pharmaceutical sector, particularly for medications targeting specific medical conditions.

Market Availability and Key Specifications

When you decide to buy 7-Chloro-1,2,3,4-Tetrahydrobenzo[b]azepin-5-one, you'll typically find it offered by specialized chemical suppliers and manufacturers. Key specifications to look for include:

  • Purity: High purity levels, often stated as ≥98.0% or ≥99.0% by HPLC, are essential for pharmaceutical applications.
  • Appearance: Usually presented as a yellow crystalline powder.
  • Melting Point: A defined melting range, typically between 95-105 °C, serves as an indicator of purity.
  • CAS Number: 160129-45-3 is the definitive identifier.
  • Packaging: Common packaging includes drums or smaller quantities suitable for laboratory use, often with options for custom packaging.

Strategic Sourcing and Supplier Selection

The global supply chain for chemical intermediates involves numerous players. For procurement managers and researchers, selecting the right supplier is critical for ensuring both quality and continuity of supply. Key factors to evaluate when you want to purchase 7-Chloro-1,2,3,4-Tetrahydrobenzo[b]azepin-5-one include:

  • Manufacturer Reputation: Prioritize manufacturers with a proven track record in producing pharmaceutical intermediates. Companies with strong quality management systems and adherence to international standards are preferred.
  • Geographical Sourcing: While global sourcing is common, manufacturers based in China often provide competitive pricing for high-quality chemical intermediates. Thorough due diligence is necessary to ensure compliance and quality.
  • Documentation: Always request a Certificate of Analysis (CoA) for each batch, which details purity, analytical methods, and compliance with specifications. Material Safety Data Sheets (MSDS) are also essential for safe handling.
  • Lead Times and Logistics: Understand the supplier's lead times for production and shipping, and ensure their logistics capabilities can meet your delivery requirements.
  • Pricing and Quotations: Obtain detailed quotes, especially for bulk orders, and compare them across multiple suppliers. Factor in shipping costs and potential import duties.

Engaging with Suppliers

To effectively buy 7-Chloro-1,2,3,4-Tetrahydrobenzo[b]azepin-5-one, direct communication with potential manufacturers is key. Reach out to suppliers, state your specific requirements, and request detailed product information and pricing. Companies that offer custom synthesis services or have strong R&D support can be particularly valuable partners, especially if you have unique project needs.

Conclusion

Navigating the market for 7-Chloro-1,2,3,4-Tetrahydrobenzo[b]azepin-5-one requires a thorough understanding of its technical specifications and a strategic approach to supplier selection. By focusing on purity, reliability, and quality documentation, procurement professionals can secure this vital intermediate, ensuring the success of their pharmaceutical synthesis projects. For those needing to purchase this chemical, engaging with reputable manufacturers is the most effective path forward.