For procurement professionals in the chemical and pharmaceutical industries, the efficient and reliable sourcing of raw materials and intermediates is a cornerstone of successful operations. 7-Chloro-1,2,3,4-Tetrahydrobenzo[b]azepin-5-one, a vital compound identified by CAS 160129-45-3, plays a significant role in complex synthesis. This guide offers insights for procurement managers aiming to purchase this intermediate with confidence.

Understanding the Product's Value Proposition

7-Chloro-1,2,3,4-Tetrahydrobenzo[b]azepin-5-one is primarily valued as a pharmaceutical intermediate. Its molecular structure (C10H10ClNO, MW: 195.65) lends itself to critical applications, most notably in the multi-step synthesis of Tolvaptan, a drug crucial for treating specific medical conditions. When you look to buy this compound, you are essentially investing in a key component that ensures the integrity and yield of your final API. The typical specifications include a high purity level, often stated as ≥99.0% by HPLC, along with controlled levels of related compounds and moisture.

Key Considerations for Procurement Managers

When tasked with purchasing 7-Chloro-1,2,3,4-Tetrahydrobenzo[b]azepin-5-one, several factors should guide your selection process:

  • Quality Assurance: The most critical aspect is ensuring product quality. Always demand a detailed Certificate of Analysis (CoA) that confirms the purity, identity, and absence of undesirable impurities. For pharmaceutical applications, adherence to strict quality standards is non-negotiable.
  • Supplier Reliability and Stability: A dependable supply chain is crucial. Evaluate potential manufacturers and suppliers based on their production capacity, track record, and ability to consistently meet delivery timelines. Businesses that can offer a stable supply agreement for this intermediate are highly valuable.
  • Manufacturing Origin: While sourcing from various regions is possible, manufacturers in China often offer competitive pricing for high-quality chemical intermediates. However, it's essential to partner with suppliers who have established quality management systems and adhere to international standards.
  • Technical Specifications: Ensure the supplier provides comprehensive technical data, including physical properties (appearance, melting point), chemical formula, molecular weight, and storage recommendations. Understanding these details helps in efficient handling and integration into your processes.
  • Cost-Effectiveness: Compare pricing from multiple reputable suppliers. While cost is a factor, it should not be prioritized over quality and supply reliability. Obtaining quotes for bulk orders can reveal significant cost savings.

Navigating the Purchase Process

To successfully buy 7-Chloro-1,2,3,4-Tetrahydrobenzo[b]azepin-5-one, initiate contact with potential suppliers to request detailed product information and pricing. Clearly outline your required quantities, purity specifications, and any specific packaging needs. A responsive supplier will be able to provide timely quotes and answer technical queries. For large-scale production, establishing a long-term partnership with a chosen manufacturer can ensure continuity and better price negotiation.

Conclusion

Procuring 7-Chloro-1,2,3,4-Tetrahydrobenzo[b]azepin-5-one requires a strategic approach that balances quality, reliability, and cost. By focusing on verified specifications, understanding the supplier's capabilities, and performing thorough due diligence, procurement managers can secure this essential intermediate for their pharmaceutical manufacturing needs. For companies looking to purchase this compound, engaging with established manufacturers known for their commitment to quality is the most effective strategy.