For procurement managers and R&D scientists in the pharmaceutical industry, sourcing high-quality chemical intermediates is paramount. One such critical compound is 2-Amidinopyrimidine Hydrochloride (CAS: 138588-40-6), a vital building block in the synthesis of various active pharmaceutical ingredients (APIs). Understanding the nuances of sourcing this intermediate, especially from global manufacturers, is key to ensuring project success and maintaining competitive pricing.

Understanding 2-Amidinopyrimidine Hydrochloride

2-Amidinopyrimidine Hydrochloride is characterized by its grey white powder appearance and high purity, typically exceeding 98%. Its primary utility lies as a pharmaceutical intermediate, notably in the synthesis of Bosentan, a medication used to treat pulmonary arterial hypertension. Its chemical structure, featuring a pyrimidine ring with an amidine group, makes it a versatile component in organic synthesis, allowing for the construction of complex molecular frameworks essential for novel drug development.

Key Considerations for Procurement Managers

When seeking to buy 2-Amidinopyrimidine Hydrochloride, procurement professionals must prioritize several factors:

  • Supplier Reliability: Identifying a 2-Amidinopyrimidine Hydrochloride manufacturer in China that offers consistent quality and reliable supply is crucial. Look for suppliers with established quality control systems, certifications (like ISO), and a proven track record in the pharmaceutical chemical sector.
  • Purity and Specifications: Ensure the supplier provides detailed specifications, including purity levels (e.g., ≥98%), appearance, and any relevant analytical data (COA). This is vital for the success of downstream synthesis reactions.
  • Regulatory Compliance and Documentation: A reputable pharmaceutical intermediate supplier will readily provide necessary documentation such as Certificates of Analysis (COA) and Material Safety Data Sheets (MSDS). For advanced projects, understanding their ability to support with DMF (Drug Master File) or EDMF is also beneficial.
  • Pricing and Lead Times: Competitive pricing is always a consideration, but it should not overshadow quality and reliability. Understanding lead times for both regular orders and larger bulk purchases is essential for production planning. Inquiring about the price of pyrimidine-2-carboximidamide hydrochloride from multiple qualified manufacturers can help secure the best value.

Why Choose a Chinese Manufacturer?

China has emerged as a global hub for chemical manufacturing, offering cost advantages and a vast production capacity. For intermediates like 2-Amidinopyrimidine Hydrochloride, partnering with an experienced Chinese CAS 138588-40-6 supplier can provide significant benefits. Companies that specialize in pharmaceutical intermediates often have dedicated R&D centers and pilot plants, enabling them to respond quickly to market demands and offer custom synthesis services.

Partnering for Success

At NINGBO INNO PHARMCHEM CO.,LTD., we understand the critical role of high-quality intermediates in pharmaceutical innovation. We are committed to being your trusted 2-Amidinopyrimidine Hydrochloride supplier, offering superior product quality, competitive pricing, and comprehensive support. By choosing us, you gain a partner dedicated to facilitating your research and manufacturing success. We invite you to contact us to discuss your specific requirements and how we can best support your projects. Let us help you source the critical building blocks for your next breakthrough.