The global market for pharmaceutical intermediates is characterized by its dynamic nature, influenced by factors such as drug development trends, manufacturing efficiencies, and raw material costs. For compounds like (2E)-2-(1,2,6,7-tetrahydrocyclopenta[e][1]benzofuran-8-ylidene)acetonitrile (CAS: 196597-79-2), understanding market dynamics, including pricing and availability, is crucial for procurement managers and R&D scientists.

(2E)-2-(1,2,6,7-tetrahydrocyclopenta[e][1]benzofuran-8-ylidene)acetonitrile serves as a key intermediate in the synthesis of Ramelteon. As such, its demand is closely tied to the market performance of this therapeutic agent and the broader pipeline of drugs utilizing similar synthetic pathways. Manufacturers in China have become significant players in the global supply of this and other pharmaceutical intermediates, often offering competitive price points due to their robust manufacturing infrastructure and scale.

When evaluating the price of (2E)-2-(1,2,6,7-tetrahydrocyclopenta[e][1]benzofuran-8-ylidene)acetonitrile, several factors come into play. These include:

  • Purity and Assay: Higher purity levels (e.g., ≥98.0%) typically command higher prices.
  • Order Volume: Bulk purchases (kilograms to tons) generally benefit from lower per-unit pricing compared to small laboratory quantities.
  • Manufacturing Complexity: The intricacies of the synthesis route and the cost of raw materials influence the final price.
  • Supplier Type: Direct manufacturers often offer more competitive prices than traders or distributors.
  • Market Demand: Fluctuations in demand for Ramelteon or related APIs can impact intermediate pricing.

Availability is also a critical consideration. Leading manufacturers, such as NINGBO INNO PHARMCHEM CO.,LTD., often maintain significant stock levels or possess flexible production capabilities to meet consistent demand. For specialized requirements, such as custom synthesis projects, lead times will vary based on the complexity of the synthesis and the production schedule. It is advisable for buyers to maintain open communication with their chosen suppliers to stay informed about current stock levels and projected lead times.

For procurement professionals seeking to buy (2E)-2-(1,2,6,7-tetrahydrocyclopenta[e][1]benzofuran-8-ylidene)acetonitrile, obtaining quotes from multiple reputable China-based manufacturers is a strategic approach to secure competitive pricing and ensure a stable supply. Understanding the market landscape empowers buyers to make informed decisions, contributing to the efficient and cost-effective development and production of essential pharmaceuticals.