For professionals in the chemical and pharmaceutical industries, a thorough understanding of product specifications is fundamental to ensuring successful research, development, and manufacturing outcomes. This article focuses on the key specifications of (2E)-2-(1,2,6,7-tetrahydrocyclopenta[e][1]benzofuran-8-ylidene)acetonitrile (CAS: 196597-79-2), a crucial intermediate widely used in the synthesis of Ramelteon and other pharmaceutical compounds.

The primary specification for any chemical intermediate is its purity, often denoted by an assay percentage. For (2E)-2-(1,2,6,7-tetrahydrocyclopenta[e][1]benzofuran-8-ylidene)acetonitrile, a common and desirable purity level is ≥98.0%. This high assay indicates a product that is largely free from impurities, which is critical for downstream reactions in API synthesis to avoid unwanted side reactions, reduce purification challenges, and ensure the final API meets regulatory standards.

Appearance is another important physical characteristic. This intermediate is typically described as a white to yellow powder. Consistency in appearance from batch to batch is a good indicator of reliable manufacturing processes and quality control by the supplier. Any significant deviation from this expected appearance could signal an issue with the product.

Other physical and chemical properties, while sometimes less critical for initial procurement, provide valuable insights for handling, storage, and reaction optimization. These include:

  • Molecular Formula: C13H11NO. This defines the elemental composition of the compound.
  • Molecular Weight: 197.232 g/mol. Essential for stoichiometric calculations in synthesis.
  • Melting Point: 146-151 °C. A narrow melting point range typically signifies good purity.
  • Density: 1.321±0.06 g/cm³. Important for physical handling and volume calculations.
  • Boiling Point: 392.1±21.0 °C at 760 mmHg. Relevant for distillation or high-temperature reactions, though often predicted.
  • Flash Point: 165.0±15.9 °C. Crucial for safety considerations during handling and storage.

Packaging is also a key specification, typically offered in drums (e.g., 25 kg/drum) and customizable according to customer requirements. Proper storage, often in a cool, ventilated place, is recommended to maintain product integrity.

For professionals looking to purchase (2E)-2-(1,2,6,7-tetrahydrocyclopenta[e][1]benzofuran-8-ylidene)acetonitrile, understanding these specifications is vital. It enables informed decision-making, facilitates effective communication with manufacturers and suppliers, and ultimately contributes to the successful execution of pharmaceutical projects. Always ensure that the product you procure aligns with these critical specifications for optimal results.