In the rigorous landscape of pharmaceutical development, the sourcing of critical chemical intermediates is a cornerstone of success. N-Benzyloxycarbonyl-L-tryptophan Methyl Ester, commonly known as Z-Trp-OMe (CAS: 2717-76-2), is a pivotal compound that plays a significant role in the synthesis of peptides and active pharmaceutical ingredients (APIs). This article aims to illuminate its importance for R&D scientists and procurement professionals, guiding them on how to effectively purchase this high-quality material from trusted suppliers.

Understanding the Chemical Profile of Z-Trp-OMe

Z-Trp-OMe is an amino acid derivative characterized by its molecular formula C20H20N2O4 and a molecular weight of 352.384. Typically supplied as a white powder with a guaranteed purity of ≥98%, it is formulated to meet the exacting standards of pharmaceutical manufacturing. The molecule features a protected tryptophan residue, with the benzyloxycarbonyl (Cbz) group safeguarding the amino terminus and a methyl ester group protecting the carboxyl terminus. This dual protection is essential for controlled chemical reactions, particularly in the sequential addition of amino acids during peptide chain elongation.

Applications in Pharmaceutical R&D

The primary utility of Z-Trp-OMe lies in its role as a versatile intermediate:

  • Peptide Synthesis: It is a fundamental building block for synthesizing therapeutic peptides, diagnostic agents, and research peptides. Its controlled reactivity ensures the formation of specific peptide bonds, crucial for the biological activity of the final product.
  • API Synthesis: Many complex APIs are built using protected amino acid fragments. Z-Trp-OMe serves as a key starting material or intermediate in pathways leading to novel drug candidates.
  • Biochemical Research: Researchers utilize this compound in studies exploring amino acid chemistry, protein interactions, and the development of modified peptides with unique properties.

Strategic Sourcing from China

For organizations looking to purchase N-Benzyloxycarbonyl-L-tryptophan Methyl Ester, China offers a robust supply base. When selecting a supplier, procurement professionals should prioritize:

  • Quality Assurance: Ensure the supplier provides comprehensive Certificates of Analysis (CoA) confirming the ≥98% purity and chemical identity.
  • Supply Chain Stability: Partner with manufacturers who can guarantee consistent availability and timely delivery to avoid disruptions in your R&D or production schedules.
  • Competitive Pricing: Obtain quotes from multiple reputable Chinese manufacturers to ensure you are getting the best market price for this essential intermediate.
  • Technical Expertise: Choose suppliers who offer technical support, helping you integrate Z-Trp-OMe effectively into your synthetic processes.

By carefully selecting a supplier and understanding the critical attributes of N-Benzyloxycarbonyl-L-tryptophan Methyl Ester, pharmaceutical companies and research institutions can ensure the quality and efficiency of their peptide synthesis and API development programs.