In the complex world of pharmaceutical synthesis, the quality and availability of key intermediates can make or break a drug development project. N-Pyridin-2-yl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide, identified by CAS number 1383385-64-5, stands out as a crucial building block in the synthesis of Acalabrutinib. Acalabrutinib is a second-generation Bruton's tyrosine kinase (BTK) inhibitor, widely used in the treatment of chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL). For R&D scientists and process chemists, understanding the properties and sourcing of this intermediate is paramount for optimizing synthesis routes and ensuring product integrity.

Chemical Characteristics and Reactivity

N-Pyridin-2-yl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide is characterized by its unique structure, incorporating a boronic ester moiety and a substituted benzamide. This chemical architecture makes it highly reactive and suitable for specific coupling reactions, such as Suzuki-Miyaura cross-coupling, which are often employed in the synthesis of complex pharmaceutical molecules like Acalabrutinib. Its stability under controlled conditions, typically requiring storage at 2-8°C, further aids in its reliable use in laboratory settings and manufacturing processes. When you need to buy this intermediate, verifying these characteristics is key to successful application.

Impact on Acalabrutinib Synthesis Efficiency

The efficiency of the Acalabrutinib synthesis pathway is directly influenced by the quality and reactivity of its intermediates. Using high-purity N-Pyridin-2-yl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide can lead to:

  • Higher Reaction Yields: A purer intermediate minimizes side reactions, leading to a greater proportion of the desired product.
  • Reduced Purification Burden: Fewer impurities in the starting material translate to simpler and more cost-effective purification of the final API.
  • Improved Batch-to-Batch Consistency: Reliable sourcing from a consistent manufacturer ensures reproducible results in your synthesis campaigns.

As a leading supplier of this essential pharmaceutical intermediate, we pride ourselves on delivering products that meet stringent purity standards (>98%). Our manufacturing processes are designed to ensure the consistent chemical integrity of N-Pyridin-2-yl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide, supporting your efforts to optimize Acalabrutinib synthesis. For researchers and procurement specialists looking to buy this compound, partnering with a reliable manufacturer like us provides the confidence needed to advance your projects efficiently. Contact our sales team for detailed product information, pricing, and to discuss bulk purchase options.