For researchers and procurement managers in the pharmaceutical and fine chemical industries, the efficient synthesis of amino acids is paramount. Diethyl Acetamidomalonate (DEAM), identified by CAS number 1068-90-2, stands out as a critical intermediate that significantly simplifies these complex processes. Understanding its capabilities and how to source it effectively can streamline your supply chain and enhance your research outcomes.

Diethyl Acetamidomalonate is a derivative of malonic acid diethyl ester, formally acetylated from unstable aminomalonic acid. Its chemical structure makes it an excellent building block for the malonic ester synthesis, a well-established method for creating α-amino acids. The process typically involves deprotonation, alkylation, hydrolysis, and decarboxylation, allowing for the precise introduction of various side chains. This versatility enables the synthesis of both natural and non-natural amino acids, which are vital for developing novel therapeutics, peptides, and biomaterials.

When considering the purchase of Diethyl Acetamidomalonate, identifying a reliable manufacturer and supplier is crucial. Companies looking to buy this intermediate often prioritize high purity (≥99.0%) and consistent availability. Sourcing from China, a global hub for chemical manufacturing, can offer cost advantages and a wide network of suppliers. For instance, partnering with a leading Chinese supplier ensures you receive a product that meets stringent quality control standards, crucial for pharmaceutical applications.

The applications of DEAM extend beyond basic amino acid synthesis. It is a key precursor in the production of important pharmaceuticals, such as Fingolimod, used in the treatment of multiple sclerosis. Furthermore, it plays a role in the synthesis of vitamins B1 and B6, as well as various barbiturates and non-steroidal anti-inflammatory agents. This broad utility underscores its importance in the chemical and pharmaceutical sectors. If you are looking to purchase Diethyl Acetamidomalonate, consider requesting a quote from reputable manufacturers in China to ensure competitive pricing and reliable supply.

When evaluating suppliers, pay attention to product specifications, including appearance (typically white to yellow or pink crystalline powder), melting point (95-98°C), and solubility (good in lower alcohols and chloroform). These details are indicative of the product's quality and suitability for your specific application. By understanding these factors and working with experienced manufacturers, procurement managers can confidently secure the necessary intermediates for their synthesis projects.