The journey of drug discovery is often a complex and iterative process, relying heavily on the availability of specialized chemical intermediates. Boc-(R)-3-amino-4-(3-benzothienyl)-butyric acid, identified by CAS number 190190-48-8, is a prime example of such a compound, playing a significant role in the synthesis of potential new therapeutics.

The Functionality of Boc-(R)-3-Amino-4-(3-benzothienyl)-butyric Acid in Discovery

This molecule offers distinct advantages for drug discovery efforts:

  • Chiral Building Block: Its specified (R)-configuration means it can be used to introduce chirality into drug candidates. In many cases, only one enantiomer of a drug is biologically active, making chiral intermediates essential for developing selective and effective treatments.
  • Boc Protection for Controlled Synthesis: The tert-butyloxycarbonyl (Boc) group provides a temporary shield for the amine, allowing chemists to perform other reactions on the molecule without interference. This controlled reactivity is vital for building complex molecular architectures found in many modern drugs. The Boc group can be removed when the amine needs to be exposed for further coupling or modification.
  • Benzothienyl Scaffold: The benzothienyl unit is a heterocycle that is frequently found in pharmaceuticals. It can contribute to a molecule's ability to bind to target proteins or pass through biological membranes, both crucial aspects of drug efficacy.

These properties make Boc-(R)-3-amino-4-(3-benzothienyl)-butyric acid a versatile tool for medicinal chemists designing novel compounds.

Applications in Drug Development Pipelines

Researchers leverage this intermediate in various stages of the drug discovery pipeline:

  • Lead Optimization: Modifying existing lead compounds by incorporating this moiety to enhance potency or improve pharmacokinetic properties.
  • Fragment-Based Drug Discovery: As a component in screening libraries to identify fragments that bind to specific biological targets.
  • Peptidomimetic Design: Creating non-peptide molecules that mimic the biological activity of peptides.

Sourcing Advice for Drug Discovery Teams

When your drug discovery team needs to buy Boc-(R)-3-amino-4-(3-benzothienyl)-butyric acid, prioritize sourcing from reputable chemical suppliers. Key considerations include purity levels (typically above 97%), the accuracy of the (R)-chirality, and reliable delivery timelines. Many manufacturers, particularly those based in China, offer competitive pricing for this intermediate. Obtaining a formal quote is recommended to compare prices and ensure you are getting the best value for your research budget. Always request a Certificate of Analysis (COA) to confirm product quality and specifications. Building relationships with trusted suppliers ensures the consistent availability of such critical building blocks for your discovery programs.

In essence, Boc-(R)-3-amino-4-(3-benzothienyl)-butyric acid is a valuable asset in the drug discovery toolkit, enabling the efficient synthesis of complex molecules with therapeutic potential.