For professionals in the pharmaceutical and chemical industries, sourcing high-quality intermediates is paramount to successful research and development. Boc-(R)-3-amino-4-(3-benzothienyl)-butyric acid, identified by CAS number 190190-48-8, stands out as a valuable building block. This article aims to guide procurement managers in understanding its significance and how to efficiently source it, particularly from manufacturers in China.

Understanding Boc-(R)-3-Amino-4-(3-benzothienyl)-butyric Acid

This specialized chemical compound is an N-protected chiral amino acid derivative. The 'Boc' group, or tert-butyloxycarbonyl, serves as a protective moiety for the amino group. This protection is essential in multi-step organic synthesis, particularly in peptide synthesis, as it prevents unwanted reactions at the amine site while allowing modifications elsewhere in the molecule. The '(R)' designation indicates a specific stereochemical configuration, which is often critical for the biological activity of the final drug product.

The presence of the 3-benzothienyl group, a fused aromatic and heterocyclic ring system, imparts unique physicochemical properties to the molecule. These properties can influence solubility, lipophilicity, and interactions with biological targets, making it a sought-after intermediate in medicinal chemistry for developing novel therapeutics.

Key Considerations for Procurement Managers

When looking to buy Boc-(R)-3-amino-4-(3-benzothienyl)-butyric acid, several factors are crucial:

  • Purity: For pharmaceutical applications, high purity is non-negotiable. Look for suppliers offering purities of 97% or above. Impurities can affect reaction yields, product quality, and the efficacy of the final API.
  • Chirality: Confirm that the product is indeed the desired (R)-enantiomer. Many syntheses require enantiomerically pure compounds to ensure the correct biological interaction.
  • CAS Number Verification: Always double-check the CAS number (190190-48-8) to ensure you are sourcing the correct material.
  • Supplier Reliability: Partnering with a reputable manufacturer or supplier is key. Consider their track record, quality control processes, and ability to provide consistent supply.

Sourcing Strategies and Commercial Aspects

For procurement managers seeking to purchase this intermediate, exploring suppliers in China can offer competitive pricing and a wide range of options. Many Chinese chemical manufacturers specialize in producing complex organic intermediates with high purity standards. When you search for a ‘Boc-(R)-3-amino-4-(3-benzothienyl)-butyric acid supplier in China,’ you are likely to find manufacturers eager to provide quotes and detailed product specifications.

To obtain the best price, it is advisable to request quotes from multiple manufacturers. Clearly state your required quantity, purity specifications, and any necessary certifications (e.g., COA). Understanding the supplier’s manufacturing capabilities, lead times, and payment terms is also vital for smooth transactions. Remember, establishing a strong relationship with a dependable supplier can streamline your procurement process for critical research chemicals.

In conclusion, Boc-(R)-3-amino-4-(3-benzothienyl)-butyric acid is a specialized yet essential component for many advanced chemical syntheses. By focusing on purity, correct stereochemistry, and reliable sourcing from manufacturers, procurement professionals can effectively support their company's innovation in drug discovery and development.