In the dynamic field of organic chemistry, the selection of appropriate building blocks and intermediates is critical for successful synthesis. 2-(2-Amino-5-bromobenzoyl) Pyridine, identified by its CAS number 1563-56-0, is a prime example of such an intermediate, valued for its unique chemical structure and reactivity. This article explores its key properties, its utility in advanced organic synthesis, and guides researchers and chemists on how to source this compound from reliable global suppliers.

Chemical Attributes of 2-(2-Amino-5-bromobenzoyl) Pyridine

This organic intermediate typically presents as a yellow solid. Its molecular formula, C12H9BrN2O, reveals the presence of a brominated phenyl ring and a pyridine moiety connected by a carbonyl group. This combination of functional groups imparts specific chemical reactivity, making it a versatile reagent. Key physical properties often highlighted include a melting point range (e.g., 98-100°C or 150-152°C depending on source), and a high degree of purity, generally above 98%. Such specifications are essential for chemists aiming for high yields and clean reaction products in their synthetic routes.

Applications in Advanced Organic Synthesis

The utility of 2-(2-Amino-5-bromobenzoyl) Pyridine in organic synthesis is multifaceted:

  • Pharmaceutical Intermediacy: As previously noted, its primary role is as a precursor in the synthesis of Bromazepam. This involves specific reaction pathways that leverage the compound's inherent chemical structure.
  • Building Block for Heterocycles: The pyridine and amino-phenyl functionalities make it a valuable starting material for constructing more complex heterocyclic systems, which are common motifs in many biologically active molecules and advanced materials.
  • Cross-Coupling Reactions: The presence of the bromine atom on the phenyl ring makes it amenable to various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira couplings), allowing for the introduction of diverse substituents and the creation of elaborate molecular architectures.
  • Research and Development: For chemists exploring new synthetic methodologies or developing novel compounds, this intermediate offers a reliable and well-characterized starting point. Purchasing this chemical allows for exploration of its reactivity in various reaction conditions.

Sourcing the Intermediate: Where to Buy

When sourcing 2-(2-Amino-5-bromobenzoyl) Pyridine, focusing on reputable suppliers is crucial to ensure product quality and reliable delivery. Whether you need a sample for initial screening or bulk quantities for ongoing projects, consider the following:

  • Manufacturer Directs: Contacting manufacturers directly, particularly those based in China which is a major chemical production hub, often provides the best balance of price and quality. Requesting a price quote for your required quantity is standard practice.
  • Specialty Chemical Suppliers: Numerous global specialty chemical distributors also stock this intermediate. They often provide a broader range of research chemicals and associated technical support.
  • Documentation: Always ensure that the supplier can provide a Certificate of Analysis (CoA) confirming purity and other relevant specifications, as well as an MSDS for safe handling.

By understanding the chemical properties and synthetic potential of 2-(2-Amino-5-bromobenzoyl) Pyridine, chemists and procurement professionals can make informed decisions when purchasing this vital intermediate. Its contribution to efficient and targeted organic synthesis makes it a valuable asset in any chemical laboratory or production facility.