The field of peptide therapeutics is rapidly expanding, driving demand for efficient and reliable methods of synthesizing complex peptide sequences. Central to these methods are protected amino acid derivatives, which allow chemists to precisely control the formation of peptide bonds. N-Acetyl-L-aspartic acid 4-tert-butyl ester (CAS 117833-18-8), often abbreviated as ac-asp(otbu)-oh, stands as a key player in this domain, offering distinct advantages for both researchers and manufacturers seeking to buy these specialized compounds.

The Chemical Design for Synthesis Success

N-Acetyl-L-aspartic acid 4-tert-butyl ester, with its chemical formula C10H17NO5, is engineered with specific protective groups designed to optimize its use in peptide synthesis. The N-acetyl group protects the alpha-amino group, while the tert-butyl ester shields the side-chain carboxyl group of aspartic acid. This dual protection is critical for several reasons:

  • Selective Coupling: It prevents unwanted side reactions, ensuring that peptide bond formation occurs exclusively between the alpha-carboxyl group of one amino acid and the alpha-amino group of the next, following standard deprotection protocols.
  • Controlled Deprotection: The tert-butyl ester is particularly advantageous as it can be cleaved under mild acidic conditions, often using trifluoroacetic acid (TFA), which is compatible with most solid-phase peptide synthesis (SPPS) strategies. This allows for the selective unmasking of the side chain after the peptide backbone is assembled.
  • Enhanced Solubility: The tert-butyl group can sometimes improve the solubility of intermediates in organic solvents commonly used in synthesis.

For research scientists needing to buy this compound, these features translate directly into higher yields and more straightforward purification processes.

Applications and Sourcing from Reliable Manufacturers

The primary application for N-Acetyl-L-aspartic acid 4-tert-butyl ester is as a building block in the synthesis of peptides, which are increasingly important in pharmaceuticals for therapeutic applications, diagnostics, and cosmetics. Its availability in a high-purity grade (typically ≥98%) is essential for researchers and pharmaceutical manufacturers who demand consistent results and compliance with stringent quality standards.

When procurement managers look to buy this intermediate, sourcing from established manufacturers, particularly in China, can offer both quality and cost advantages. A good supplier will provide comprehensive documentation, including Certificates of Analysis, and ensure proper storage conditions (typically 2-8°C) to maintain product integrity. Engaging with manufacturers directly allows for better pricing negotiations and a more robust understanding of production capabilities.

The Broader Impact on R&D

By providing a reliable source of high-quality protected amino acids like N-Acetyl-L-aspartic acid 4-tert-butyl ester, chemical manufacturers empower researchers to focus on groundbreaking discovery. The efficiency gained through using well-designed intermediates contributes to faster drug development cycles and enables the exploration of novel peptide sequences with unique therapeutic properties. For companies looking to purchase this compound, partnering with a trusted supplier is an investment in their research and development pipeline.

Conclusion: Advancing Peptide Science Through Quality Intermediates

N-Acetyl-L-aspartic acid 4-tert-butyl ester exemplifies the importance of specialized chemical intermediates in modern scientific advancement. Its strategic design for peptide synthesis, coupled with the availability of high-purity grades from reliable manufacturers, makes it an indispensable tool for progress in pharmaceutical research and beyond.