In the highly regulated and precision-driven pharmaceutical industry, the quality of every component, especially key intermediates, directly impacts the efficacy and safety of the final drug product. 4-Nitrobenzyl Hydrogen Malonate (CAS 77359-11-6) is a prime example of such a critical intermediate, playing a significant role in the synthesis of vital antibiotics.

Key Chemical Properties and Purity

4-Nitrobenzyl Hydrogen Malonate, with the chemical formula C10H9NO6, is known for its characteristic appearance as a white to almost white powder. Its melting point is consistently reported at 109°C, a key indicator of its purity and consistency. Manufacturers typically offer this compound with an assay of 99% or higher, a specification that is non-negotiable for pharmaceutical applications. Its solubility in methanol facilitates its integration into standard organic synthesis workflows. These attributes make it a reliable choice for complex chemical processes, particularly in the pharmaceutical sector.

Industrial Applications: A Focus on Antibiotics

The primary industrial application for 4-Nitrobenzyl Hydrogen Malonate is as a crucial intermediate in the production of beta-lactam antibiotics. Specifically, it is indispensable for the synthesis of (±)-thienamycin and serves as a key chiral building block for carbapenem antibiotics. These drug classes are vital in combating a wide range of bacterial infections, including those caused by multi-drug resistant pathogens. For pharmaceutical companies involved in antibiotic research, development, or manufacturing, sourcing this specific malonate derivative is a fundamental step.

Procuring 4-Nitrobenzyl Hydrogen Malonate: A Strategic Choice

When seeking to buy 4-Nitrobenzyl Hydrogen Malonate, focusing on suppliers who can offer a stable, high-purity supply is essential. Manufacturers in China are often competitive sources, providing materials that meet stringent pharmaceutical standards. For procurement managers and R&D scientists, establishing a relationship with a dependable supplier ensures not only the quality of the intermediate but also competitive pricing and timely delivery, which are critical for managing project timelines and budgets effectively. Engaging with a manufacturer directly can often streamline the procurement process and offer valuable technical support.

In conclusion, the strategic use of high-purity 4-Nitrobenzyl Hydrogen Malonate from reputable suppliers is fundamental to the successful synthesis of essential antibiotics, contributing significantly to global health initiatives.