The pharmaceutical industry's ability to combat infectious diseases relies on the efficient synthesis of potent therapeutic agents. Critical chemical intermediates form the backbone of these manufacturing processes, and 4-Nitrobenzyl Hydrogen Malonate (CAS 77359-11-6) is a prime example of such an indispensable compound.

Chemical Properties and Specifications

4-Nitrobenzyl Hydrogen Malonate is defined by its chemical formula C10H9NO6 and a molecular weight of 239.18. It is typically supplied as a white to almost white powder, with a precise melting point of 109°C. Its solubility in methanol is a practical advantage for chemists conducting synthesis reactions. Manufacturers strive to provide this intermediate with a minimum purity of 99%, ensuring it meets the rigorous demands of pharmaceutical research and production.

Role in Antibiotic Synthesis

The principal application of 4-Nitrobenzyl Hydrogen Malonate is its function as a key intermediate in the synthesis of vital antibiotics. It is particularly integral to the production of beta-lactam antibiotics, such as thienamycin, and serves as a crucial chiral building block for carbapenem antibiotics. These classes of drugs are essential for treating serious bacterial infections, including those caused by resistant strains. Researchers and product formulators depend on the high quality and reliable supply of this intermediate to develop and manufacture these life-saving medications.

Procurement Strategies for Pharmaceutical Intermediates

For pharmaceutical companies needing to buy 4-Nitrobenzyl Hydrogen Malonate, partnering with reputable manufacturers and suppliers is paramount. Sourcing from established chemical providers, particularly those with strong manufacturing capabilities in China, can offer significant benefits in terms of cost-effectiveness and product quality. When evaluating suppliers, key considerations include assay purity, consistency of supply, timely delivery, and the availability of comprehensive technical documentation like Certificates of Analysis (CoA). Building a reliable supply chain for critical intermediates like this is fundamental to operational success in the pharmaceutical sector.

By ensuring access to high-quality 4-Nitrobenzyl Hydrogen Malonate from trusted sources, the pharmaceutical industry can continue to innovate and produce the antibiotics necessary to address global health challenges.