For chemists engaged in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals, the choice of starting materials and intermediates can profoundly influence the outcome of their work. 1,3-Dichloro-4-fluorobenzene, identified by its CAS number 1435-48-9, is a versatile halogenated aromatic compound that plays a significant role in many synthetic pathways. This guide aims to provide chemists with insights into its properties, optimal usage, and the importance of sourcing from reputable manufacturers and suppliers.

Understanding the Reactivity of 1,3-Dichloro-4-fluorobenzene

1,3-Dichloro-4-fluorobenzene (C6H3Cl2F, MW 164.99) is a highly functionalized benzene derivative. The presence of two chlorine atoms and one fluorine atom dictates its reactivity, primarily in electrophilic aromatic substitution reactions. Chemists can leverage these halogen substituents for various transformations, including nucleophilic aromatic substitution under specific conditions, or as points for metal-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira). Its physical state as a clear, colorless to yellow liquid at room temperature (Melting Point: -23 °C, Boiling Point: 172-174 °C) makes it relatively easy to handle in most laboratory settings.

Key Considerations for Synthetic Chemists

When a chemist plans to buy 1,3-Dichloro-4-fluorobenzene for a synthetic project, several factors are crucial for success:

  • Purity is Paramount: For complex organic synthesis, especially in pharmaceutical applications, high purity is essential. Impurities can lead to side reactions, reduced yields, and complicate purification procedures. Always ensure your supplier provides a detailed CoA confirming purity levels, often exceeding 99%.
  • Reaction Conditions Optimization: Understanding the electronic effects of the halogens is key. The fluorine atom is electron-withdrawing, influencing the regioselectivity of reactions. Chemists may need to adjust catalysts, temperatures, solvents, and reaction times to achieve desired outcomes.
  • Solubility and Handling: Being an organic liquid, it is soluble in most common organic solvents (e.g., ethanol, DMF, toluene). Standard laboratory safety precautions, including good ventilation and appropriate personal protective equipment (gloves, eye protection), should always be followed.
  • Scale-Up Considerations: If a synthesis is intended for larger-scale production, it is vital to work with a manufacturer who can provide consistent quality and sufficient volume. The price for bulk quantities should be negotiated well in advance.

The Role of the Supplier in Synthesis Success

The quality of your 1,3-Dichloro-4-fluorobenzene directly impacts the efficiency and success of your synthetic endeavors. Working with a reliable supplier or manufacturer offers several advantages:

  • Consistent Quality: A good supplier ensures batch-to-batch consistency, which is critical for reproducible synthetic results.
  • Technical Data Availability: Access to detailed technical information, including spectral data if needed, can aid in reaction design and troubleshooting.
  • Timely Delivery: Ensuring you can procure the material when needed is vital for keeping research projects on track.

Chemists looking to efficiently utilize 1,3-Dichloro-4-fluorobenzene should prioritize sourcing from reputable manufacturers known for their quality control and reliability. Whether for initial research or bulk production, securing a consistent supply of high-purity material is a cornerstone of successful organic synthesis.