In the realm of organic chemistry, the search for versatile building blocks that can facilitate complex synthesis is perpetual. (3,4-Dimethoxyphenyl)acetonitrile (CAS 93-17-4) stands out as one such compound, offering a unique combination of functional groups that make it invaluable for a wide array of synthetic applications, extending beyond its well-known role in pharmaceutical intermediate production. For R&D scientists and synthetic chemists, understanding the potential of this molecule can unlock new avenues in chemical innovation. This article explores the multifaceted applications of (3,4-Dimethoxyphenyl)acetonitrile in organic synthesis and guides researchers on sourcing this essential chemical.

The Chemical Profile of (3,4-Dimethoxyphenyl)acetonitrile

At its core, (3,4-Dimethoxyphenyl)acetonitrile is characterized by its phenyl ring adorned with two methoxy groups at the 3 and 4 positions, coupled with an acetonitrile side chain. This structure, represented by the molecular formula C10H11NO2 and a molecular weight of 177.2, provides multiple sites for chemical reactivity. The nitrile group (-CN) can be readily transformed into various other functional groups, such as carboxylic acids, amines, or amides, through standard organic reactions. The aromatic ring, activated by the electron-donating methoxy groups, can also undergo electrophilic aromatic substitution reactions.

Beyond Pharmaceuticals: Diverse Synthetic Pathways

While its most prominent use is as an intermediate in the synthesis of pharmaceuticals like cefuroxime and as an impurity reference for drugs such as Verapamil, (3,4-Dimethoxyphenyl)acetonitrile is also a valuable reagent in general organic synthesis. Its utility stems from its ability to:

  • Act as a Carbon Nucleophile: The alpha-carbon to the nitrile group possesses some acidity and can be deprotonated to form a carbanion, which can then react with electrophiles. This opens pathways to form new carbon-carbon bonds, extending molecular frameworks.
  • Serve as a Nitrile Precursor: The nitrile group itself can be hydrolyzed to a carboxylic acid, reduced to a primary amine, or reacted with Grignard reagents to form ketones, offering diverse functional group transformations.
  • Participate in Cyclization Reactions: In specific synthetic strategies, the molecule can be incorporated into cyclization reactions, leading to the formation of heterocyclic compounds or complex ring systems. For instance, research has shown its use in the synthesis of compounds involving cyclization of acrylonitrile derivatives.
  • Be a Starting Material for Specialty Chemicals: Its structure can be modified to create specialized molecules for various industrial applications, including materials science or agrochemicals, depending on the desired properties.

The flexibility of (3,4-Dimethoxyphenyl)acetonitrile makes it an attractive option for chemists designing novel synthetic routes or looking to optimize existing ones. Researchers often seek high-purity grades of such intermediates to ensure predictable reaction outcomes and minimize purification challenges.

Procuring (3,4-Dimethoxyphenyl)acetonitrile for Your Research

For organic synthesis laboratories and chemical R&D departments, securing a reliable supply of (3,4-Dimethoxyphenyl)acetonitrile is crucial. When purchasing, consider suppliers who offer:

  • High Purity Grades: Essential for predictable reaction outcomes and to avoid interference from impurities.
  • Detailed Specifications: A clear breakdown of physical and chemical properties, including spectral data if available.
  • Availability in Research Quantities: Suppliers catering to R&D needs often provide smaller pack sizes suitable for laboratory experiments.
  • Competitive Pricing: Even for research quantities, cost-effectiveness is important, and comparing prices from reputable manufacturers is recommended.

Companies like NINGBO INNO PHARMCHEM CO.,LTD., a prominent manufacturer and supplier from China, offer (3,4-Dimethoxyphenyl)acetonitrile that meets the stringent requirements of organic synthesis. Their commitment to quality ensures that researchers can rely on the material for their demanding experimental protocols.

In conclusion, (3,4-Dimethoxyphenyl)acetonitrile (CAS 93-17-4) is a compound of significant value in organic synthesis. Its inherent reactivity and the potential for diverse functional group transformations make it a versatile building block for creating a wide range of complex molecules. By partnering with reliable suppliers, researchers can access this essential chemical to drive innovation in chemical science.