The pharmaceutical industry relies heavily on the precise synthesis of complex organic molecules to develop life-saving drugs. At the heart of this process are chemical intermediates – the fundamental building blocks that enable chemists to construct intricate molecular architectures. One such crucial intermediate is 2-Bromo-4-tert-butylpyridine, identified by its CAS number 50488-34-1. Its unique chemical characteristics make it an indispensable component in the creation of various pharmaceutical compounds.

Understanding the Chemical Profile of 2-Bromo-4-tert-butylpyridine

With the molecular formula C9H12BrN and a molecular weight of 214.10, 2-Bromo-4-tert-butylpyridine is a pyridine derivative known for its specific reactivity. Typically appearing as a colorless to light yellow liquid or solid, it boasts a boiling point of 243.6°C at atmospheric pressure and a density of 1.293 g/cm³. The key to its utility lies in the bromine atom at the 2-position of the pyridine ring, which readily participates in a variety of synthetic transformations, including palladium-catalyzed cross-coupling reactions like Suzuki, Heck, and Sonogashira couplings. These reactions are fundamental in building complex carbon-carbon bonds, a common requirement in API synthesis. The tert-butyl group at the 4-position provides steric bulk, which can influence regioselectivity and reaction kinetics, allowing chemists greater control over the synthetic outcome.

2-Bromo-4-tert-butylpyridine as a Pharmaceutical Intermediate

In pharmaceutical manufacturing, 2-Bromo-4-tert-butylpyridine serves as a critical intermediate for the synthesis of a wide range of APIs. Its structure can be modified to incorporate specific functionalities that are essential for a drug's therapeutic effect. For instance, it can be coupled with various boronic acids, organometallic reagents, or amines to build the complex heterocyclic scaffolds characteristic of many modern pharmaceuticals. Procurement managers seeking to buy this compound often look for suppliers who can guarantee high purity (often 97% min) and reliable batch-to-batch consistency, which are critical for GMP-compliant manufacturing processes. Sourcing from experienced manufacturers in China can provide access to these quality standards at competitive price points.

The demand for such intermediates necessitates a robust supply chain. Pharmaceutical companies often establish long-term relationships with suppliers who can ensure timely delivery and consistent quality. The ability to purchase in bulk, along with responsive technical support, further solidifies these partnerships. When you choose to purchase 2-Bromo-4-tert-butylpyridine from a dedicated manufacturer, you are investing in the reliability of your production pipeline.

Sourcing Strategies and Future Outlook

The global market for pharmaceutical intermediates is highly competitive, with manufacturers in China playing a significant role. When looking to buy 2-Bromo-4-tert-butylpyridine, attention to detail regarding supplier credentials, quality control processes, and pricing structures is essential. Companies that prioritize these aspects are better positioned to secure the materials needed for successful drug development and manufacturing. The consistent availability of high-quality intermediates like this pyridine derivative is vital for the continued innovation and growth within the pharmaceutical sector.

In summary, 2-Bromo-4-tert-butylpyridine (CAS 50488-34-1) is a cornerstone intermediate in pharmaceutical synthesis. Its reactive bromine atom and characteristic tert-butyl group offer chemists a powerful tool for building complex molecules. For those in the pharmaceutical industry looking to purchase this vital compound, partnering with a reliable manufacturer, particularly from China, ensures access to high-quality materials at competitive prices, thereby supporting the relentless pursuit of new therapeutic solutions.