For professionals in the pharmaceutical and fine chemical industries, understanding the market dynamics, including the price and availability of key chemical intermediates, is crucial for effective procurement. 7-Bromo-2-(chloroacetyl)-9,9-difluorofluorene, more commonly known by its CAS number 1378387-81-5, is a specialized compound vital for the synthesis of Ledipasvir and other complex organic molecules. When planning to purchase this compound, buyers often seek clarity on pricing structures and how to secure a consistent supply.

Factors Influencing Price

The cost of 7-Bromo-2-(chloroacetyl)-9,9-difluorofluorene is influenced by several factors, inherent to the chemical manufacturing industry:

  • Purity Level: As a pharmaceutical intermediate, high purity (typically ≥99%) is essential. Higher purity grades require more complex synthesis and purification processes, thus commanding a higher price.
  • Production Scale: The cost per unit often decreases with larger order volumes due to economies of scale in manufacturing. Small R&D quantities will naturally be more expensive per gram than bulk industrial orders.
  • Raw Material Costs: Fluctuations in the prices of precursor chemicals and reagents directly impact the final product cost.
  • Manufacturing Complexity: The synthesis of difluorinated fluorene derivatives involves specialized techniques and equipment, contributing to the overall production cost.
  • Supplier's Overhead and Certifications: Manufacturers with GMP or ISO 9001 certifications, robust R&D departments, and extensive export experience may have higher operational costs reflected in their pricing.
  • Market Demand: As with any commodity, supply and demand dynamics play a significant role in price fluctuations.

Ensuring Availability and Securing Supply

Availability is closely tied to a supplier's production capacity and their ability to manage their inventory effectively. For critical intermediates like 7-Bromo-2-(chloroacetyl)-9,9-difluorofluorene, it is advisable to:

  • Identify Reputable Manufacturers: Work with established chemical companies, particularly those with a strong presence in China, known for their pharmaceutical intermediate production. NINGBO INNO PHARMCHEM CO.,LTD. is an example of a company committed to quality supply.
  • Request Quotations and Samples: Obtain detailed quotes for your required quantities and request samples for quality verification. This also helps gauge the supplier's responsiveness.
  • Establish Long-Term Relationships: For ongoing needs, developing a relationship with a reliable manufacturer can ensure consistent supply and potentially better pricing over time.
  • Understand Lead Times: Be aware of the production and shipping lead times to plan your procurement effectively.

By approaching the procurement of 7-Bromo-2-(chloroacetyl)-9,9-difluorofluorene with a clear understanding of these factors, buyers can make informed decisions, secure competitive pricing, and ensure the consistent availability of this vital chemical for their operations.