For procurement managers and R&D scientists in the pharmaceutical industry, sourcing critical intermediates like 1-(7-Bromo-9,9-difluoro-9H-fluoren-2-yl)-2-chloro-Ethanone (CAS: 1378387-81-5) is a meticulous process. This compound, essential for the synthesis of Ledipasvir, demands high purity and reliable supply. When looking to buy this vital pharmaceutical intermediate, understanding the nuances of procurement from global manufacturers, particularly from China, is key to ensuring quality and cost-effectiveness.

Understanding the Intermediate's Role

1-(7-Bromo-9,9-difluoro-9H-fluoren-2-yl)-2-chloro-Ethanone serves as a cornerstone in the complex synthetic pathway of Ledipasvir, an active pharmaceutical ingredient (API) crucial for treating Hepatitis C. Its chemical structure, a difluorinated fluorene derivative with bromine and chloroacetyl substituents, makes it a specialized building block. The demand for high purity, typically exceeding 99%, is non-negotiable for pharmaceutical applications to guarantee the efficacy and safety of the final drug product.

Key Considerations for Buyers

When engaging with suppliers for this intermediate, several factors should be paramount. Firstly, quality assurance is critical. Look for manufacturers that can provide comprehensive Certificates of Analysis (CoA) detailing purity, impurities, and physical properties. Certifications like GMP (Good Manufacturing Practice) and ISO 9001 are strong indicators of a supplier's commitment to quality management systems. Companies like NINGBO INNO PHARMCHEM CO.,LTD. often prioritize these standards.

Secondly, supplier reliability and capacity are crucial. The ability of a manufacturer to consistently produce and deliver the required quantities, even for large-scale orders, is vital for uninterrupted production. Understanding a supplier's production capacity and their track record in meeting delivery timelines is essential. Asking about their export experience can also provide insight into their logistical capabilities.

Thirdly, pricing and commercial terms need careful negotiation. While cost is always a consideration, it should be balanced against quality and reliability. Requesting samples for in-house testing is a standard practice to verify quality before committing to a larger purchase. Discussing payment terms and delivery options (e.g., FOB, CIF) will help establish a clear commercial agreement.

Navigating the Chinese Market

China has emerged as a significant hub for chemical manufacturing, including pharmaceutical intermediates. For buyers seeking 1-(7-Bromo-9,9-difluoro-9H-fluoren-2-yl)-2-chloro-Ethanone, partnering with reputable Chinese manufacturers can offer a strategic advantage in terms of cost and access to a broad production base. However, due diligence is essential. Platforms that list verified suppliers and provide company audit reports can be invaluable resources.

How to Buy Effectively

To effectively purchase this intermediate, draft a clear inquiry that includes:

  • The exact chemical name and CAS number (1378387-81-5).
  • Required purity level (e.g., ≥99%).
  • Estimated quantity needed (e.g., kg, tons).
  • Desired delivery timeframe.
  • Request for a quotation and sample availability.

Engaging with a company that can offer both product expertise and logistical support, such as NINGBO INNO PHARMCHEM CO.,LTD., can streamline your procurement process. By focusing on these key aspects, pharmaceutical professionals can ensure a stable and high-quality supply of critical intermediates for their vital drug development and manufacturing operations.