For professionals in pharmaceutical research, development, and fine chemical manufacturing, understanding where and how to procure essential intermediates is a critical aspect of their work. Methyl 2-Oxoindoline-6-carboxylate (CAS 14192-26-8) is a notable compound, widely recognized for its application as a key intermediate in the synthesis of Nintedanib, among other potential uses in medicinal chemistry. This guide aims to provide clarity on its characteristics and the procurement process.

Methyl 2-Oxoindoline-6-carboxylate is typically supplied as an off-white powder, a convenient form for laboratory use and industrial processes. Its chemical identity is defined by its formula C10H9NO3, and its molecular weight is approximately 191.183. The purity of the compound is a primary concern for its end-users, with industry standards often requiring levels of 98.0% or higher. This high purity is essential for ensuring the success of complex synthetic pathways and the quality of the final product, particularly in pharmaceutical applications where even minor impurities can have significant consequences. Therefore, when you decide to buy Methyl 2-Oxoindoline-6-carboxylate, prioritizing suppliers who can guarantee this level of purity is paramount.

The most well-documented application of Methyl 2-Oxoindoline-6-carboxylate is its role as a crucial intermediate in the synthesis of Nintedanib. Nintedanib is a vital drug used to treat conditions such as idiopathic pulmonary fibrosis and certain types of cancer. As a result, demand for this intermediate remains strong in the pharmaceutical sector. Beyond this primary use, its indole-based structure makes it a valuable building block for chemists engaged in the discovery of new therapeutic agents and other complex organic molecules. Its versatility as a chemical scaffold is a key reason for its importance in R&D.

When sourcing Methyl 2-Oxoindoline-6-carboxylate, consider working with specialized chemical suppliers and manufacturers. Companies based in China, for instance, have become major players in the global supply of pharmaceutical intermediates, offering competitive pricing and large-scale production capabilities. To secure the best value and ensure reliability, it is advisable to investigate potential suppliers thoroughly. Look for those who provide comprehensive product documentation, have established quality control systems, and can demonstrate a consistent supply capability. Understanding their pricing structures, minimum order quantities, and delivery timelines will further aid in making an informed procurement decision.

In essence, the effective procurement of Methyl 2-Oxoindoline-6-carboxylate requires a strategic approach. By focusing on purity, understanding its applications, and partnering with reputable manufacturers and suppliers, researchers and industrial chemists can ensure they obtain a high-quality product that supports their critical projects and production needs.