For procurement specialists in the chemical and pharmaceutical industries, sourcing high-quality raw materials efficiently is a cornerstone of operational success. N-Cbz-Glycine Ethyl Ester (CAS 1145-81-9) is a critical intermediate, and understanding how to procure it effectively, especially from China, is essential. This guide will walk you through its importance, quality considerations, and the procurement process.

Why N-Cbz-Glycine Ethyl Ester is Crucial

N-Cbz-Glycine Ethyl Ester is a protected form of the amino acid glycine. The N-Cbz (benzyloxycarbonyl) group acts as a protecting agent for the amine function, a common requirement in multi-step organic synthesis. The ethyl ester group protects the carboxylic acid. This dual protection is highly valued in:

  • Pharmaceutical Synthesis: It's a key intermediate for producing Active Pharmaceutical Ingredients (APIs) and complex drug molecules. Its controlled reactivity allows for precise construction of the target compounds. For anyone needing to buy N-Cbz-Glycine Ethyl Ester for R&D or manufacturing, understanding its purity specifications is vital.
  • Peptide Synthesis: In creating therapeutic peptides, N-Cbz-Glycine Ethyl Ester is used to incorporate glycine into the growing peptide chain, ensuring the correct sequence is built without unwanted side reactions.
  • Advanced Organic Chemistry: Researchers utilize it in various organic transformations where selective protection of amino and carboxyl groups is necessary.

Key Quality Parameters to Consider

When you plan to purchase N-Cbz-Glycine Ethyl Ester, pay close attention to these quality indicators:

  • Purity: High purity, typically 98% or 99% and above, is critical for its efficacy in sensitive synthesis processes. Always request a Certificate of Analysis (CoA) from the supplier.
  • Appearance: The compound is generally a white powder. Any deviation from this description might indicate an issue with quality or handling.
  • CAS Number Verification: Ensure the CAS number 1145-81-9 is correctly listed for the product you are sourcing.

Sourcing Strategy: Leveraging Chinese Manufacturers

China has a well-established chemical manufacturing industry, making it a prime location to source N-Cbz-Glycine Ethyl Ester. Here’s how to approach procurement:

  • Identify Reputable Suppliers: Look for manufacturers with experience in producing pharmaceutical intermediates and a history of consistent quality. Many Chinese suppliers list their products on global trade platforms, offering detailed product information and supplier credentials.
  • Request Quotes and Samples: Once potential suppliers are identified, request formal quotes to compare N-Cbz-Glycine Ethyl Ester prices. Ordering small sample quantities for in-house testing is a prudent step before committing to larger orders.
  • Evaluate Lead Times and Logistics: Discuss shipping options, lead times, and packaging to ensure the material arrives when and how you need it. Consider the logistics for importing chemicals into your country.
  • Build a Relationship: Developing a strong working relationship with a chosen manufacturer can lead to better pricing, priority service, and more reliable supply in the long term.

By following these guidelines, procurement professionals can confidently source N-Cbz-Glycine Ethyl Ester from China, ensuring their research and production lines are supported by high-quality, cost-effective chemical intermediates.