For procurement managers in the pharmaceutical and biotechnology industries, sourcing critical raw materials like Z-His-OH (CAS: 14997-58-1) requires a strategic approach. This N-alpha-carbobenzyloxy-L-histidine derivative is a cornerstone in peptide synthesis and is vital for drug discovery and development. Understanding the market, key quality indicators, and reliable manufacturers is essential for efficient and effective procurement.

Z-His-OH, also referred to as Cbz-His-OH, is a protected form of the amino acid histidine, crucial for introducing histidine residues into peptide chains. Its specific chemical structure, featuring the Z (carbobenzyloxy) protecting group, allows for controlled peptide bond formation, preventing side reactions and ensuring the integrity of the growing peptide. The imidazole ring of histidine itself can also participate in various biochemical interactions, making Z-His-OH a valuable component for synthesizing peptides with targeted biological activities.

When sourcing Z-His-OH, procurement professionals often search for Z-His-OH price information to evaluate suppliers. While competitive pricing is a significant factor, it should be balanced with the assurance of high purity and reliable supply. Manufacturers based in regions like China are often competitive suppliers, offering Z-His-OH for sale at attractive price points. However, it is imperative to work with a Z-His-OH manufacturer that adheres to strict quality control standards, providing consistent batch quality and comprehensive documentation like SDS and CoA.

The process of purchasing Z-His-OH typically involves requesting quotes from multiple suppliers. Key considerations during this process include:

1. Purity Levels: Ensure the Z-His-OH meets or exceeds the required purity, often specified as ≥ 99% by HPLC. Impurities can lead to significant problems in downstream peptide synthesis, impacting yield and the final product's efficacy.

2. Supply Chain Reliability: A dependable supplier is crucial. Investigate their production capacity, lead times, and track record for on-time delivery. For critical R&D projects, securing a stable supply of CAS 14997-58-1 is non-negotiable.

3. Technical Support and Documentation: Reputable suppliers offer robust technical support and provide essential documentation. This includes Safety Data Sheets (SDS) for safe handling and Certificates of Analysis (CoA) detailing the purity and specifications of each batch.

4. Pricing and Payment Terms: Compare pricing structures, including volume discounts and payment terms. For larger orders, negotiating favorable terms can significantly impact project budgets.

For procurement managers needing to buy Z-His-OH online, it is advisable to cross-reference product information from multiple sources and engage directly with manufacturers or their authorized distributors. Understanding the nuances of sourcing this vital chemical intermediate will lead to more successful research outcomes and efficient R&D operations. Choosing a trusted Z-His-OH supplier is an investment in the quality and progress of your pharmaceutical research.