While Z-His-OH (CAS: 14997-58-1) is most prominently recognized for its indispensable role in peptide synthesis, its utility as a versatile chemical building block extends into broader applications within organic chemistry and fine chemical manufacturing. This protected amino acid derivative, N-alpha-Carbobenzyloxy-L-histidine, offers a unique combination of functionalities that make it valuable for creating a diverse array of complex organic molecules.

The core structure of Z-His-OH features the L-histidine amino acid, characterized by its imidazole ring side chain. This imidazole moiety is a nitrogen-containing heterocycle that can participate in a variety of chemical reactions, including nucleophilic substitutions, electrophilic attacks, and coordination with metal ions. Coupled with the alpha-amino group protected by the carbobenzyloxy (Z) group and the carboxyl group, Z-His-OH presents multiple points for chemical modification and elaboration.

In organic synthesis, chemists often seek starting materials that can introduce specific functional groups or heterocyclic systems into target molecules. Z-His-OH fulfills this role effectively. For instance, the imidazole ring can be derivatized, alkylated, or used in coupling reactions to form new carbon-carbon or carbon-heteroatom bonds. The protected carboxyl group can be activated for esterification or amidation, further expanding the synthetic possibilities. Researchers often look to buy Z-His-OH when designing synthetic routes for biologically active compounds, pharmaceuticals, or advanced materials.

Beyond its application in peptide bond formation, Z-His-OH can be employed in the synthesis of:

  1. Medicinal Chemistry Intermediates: Its structure can be incorporated into scaffolds for new drug candidates, especially those targeting pathways where histidine's chemical properties are crucial, such as metalloenzymes.
  2. Ligands for Catalysis: The imidazole ring's ability to coordinate with metal ions makes Z-His-OH and its derivatives potential ligands for homogeneous catalysis.
  3. Functional Materials: The unique properties of the imidazole ring could be exploited in the development of specialized polymers or surface modification agents.

For chemical manufacturers and procurement specialists, sourcing Z-His-OH requires attention to purity and consistency. A reliable Z-His-OH manufacturer or supplier is key to ensuring that the material meets the stringent requirements for complex organic synthesis. While searching for the best Z-His-OH price, it is important to consider the overall value, including product quality, availability, and the supplier's technical support. Companies looking to secure a consistent supply of CAS 14997-58-1 for their fine chemical production should prioritize partnerships with established chemical suppliers.

In conclusion, the versatility of Z-His-OH as a chemical building block should not be underestimated. Its reactive functionalities and inherent structural features make it a valuable asset for synthetic chemists aiming to construct intricate organic molecules for a wide range of applications, from pharmaceuticals to advanced materials. A dependable supply from a qualified Z-His-OH supplier empowers innovation in chemical synthesis.