The demand for specialized heterocyclic compounds as building blocks in the pharmaceutical, agrochemical, and material science sectors continues to grow. Among these, pyrido[2,3-d]pyrimidine derivatives stand out due to their presence in numerous biologically active molecules and functional materials. For R&D scientists and procurement professionals, securing a reliable supply of such complex intermediates is critical. This article focuses on the procurement of 6-Bromo-4-chloropyrido[2,3-d]pyrimidine (CAS: 1215787-31-7), detailing essential considerations when sourcing from manufacturers, particularly in the competitive Chinese market.

Understanding the Building Block: 6-Bromo-4-chloropyrido[2,3-d]pyrimidine is a key intermediate characterized by its fused nitrogen-containing heterocyclic ring system. The CAS number 1215787-31-7 uniquely identifies this compound. Its molecular formula (C7H3BrClN3) and molecular weight (244.48 g/mol) are standard identifiers. Physically, it is typically supplied as a white to yellow crystalline solid, with a melting point of 152-154 °C. These properties are important for its handling and initial quality checks.

Strategic Sourcing and Supplier Selection: The global chemical supply chain is highly interconnected, with China playing a dominant role in the manufacturing of fine chemicals and intermediates. When you look to buy 6-Bromo-4-chloropyrido[2,3-d]pyrimidine, identifying reputable Chinese manufacturers is a common strategy. Key factors in supplier selection include:

  • Product Quality and Purity: Ensuring the intermediate meets the required purity specifications (e.g., ≥95%) is paramount, especially for pharmaceutical applications. Requesting a Certificate of Analysis (CoA) from the manufacturer is standard practice.
  • Manufacturing Capabilities: Understanding the synthesis route and the manufacturer's adherence to good manufacturing practices (GMP) or ISO standards can provide confidence in product consistency.
  • Pricing and Quotations: Obtaining multiple quotes for the desired quantity is essential. The price of 6-Bromo-4-chloropyrido[2,3-d]pyrimidine can vary based on supplier, order volume, and current market conditions.
  • Lead Times and Reliability: Timely delivery is crucial for R&D projects. Confirming lead times and the supplier's track record for reliability is important.
  • Technical Support: A responsive supplier who can offer technical assistance regarding product handling, storage, and potential applications adds significant value.

Synthesis and Quality Control: The synthesis of 6-Bromo-4-chloropyrido[2,3-d]pyrimidine often starts from precursor molecules and involves chemical transformations, such as chlorination reactions using reagents like POCl3. Manufacturers employ various purification techniques, like recrystallization, to achieve the specified purity. The presence of detailed analytical data, such as NMR and HPLC results, in the CoA is vital for verifying the product's identity and purity before purchase.

The Importance of Free Samples and Bulk Inquiries: For significant procurement needs, requesting a free sample allows R&D teams to validate the intermediate's suitability for their specific reactions and quality requirements. For larger-scale production, conducting a bulk inquiry with potential manufacturers is the next step. This typically involves specifying the required quantity, desired purity, and delivery timelines to receive tailored quotations and production schedules.

In conclusion, the procurement of specialized heterocyclic building blocks like 6-Bromo-4-chloropyrido[2,3-d]pyrimidine requires a methodical approach. By carefully selecting suppliers, verifying quality through CoAs, and understanding market pricing and lead times, researchers and procurement specialists can ensure the efficient and cost-effective acquisition of this vital chemical intermediate, thereby supporting innovation across various scientific disciplines.