The pharmaceutical industry thrives on innovation, driven by the discovery and development of novel therapeutic agents. At the heart of this process lie chemical intermediates – the molecular building blocks that enable the construction of complex drug molecules. 6-Bromo-4-chloropyrido[2,3-d]pyrimidine, identified by its CAS number 1215787-31-7, is one such critical intermediate, particularly valued in the synthesis of compounds with potential pharmacological activity. For R&D scientists and procurement specialists, understanding its utility and how to source it effectively from chemical manufacturers is paramount.

Why 6-Bromo-4-chloropyrido[2,3-d]pyrimidine is Important: The pyrido[2,3-d]pyrimidine core is a privileged structure in medicinal chemistry, meaning it is frequently found in biologically active molecules. The presence of strategically placed bromine and chlorine atoms on this core in 6-Bromo-4-chloropyrido[2,3-d]pyrimidine provides chemists with versatile handles for further modification. These halogens can be selectively replaced or coupled through various chemical reactions, allowing for the introduction of diverse functional groups. This chemical versatility is essential for exploring structure-activity relationships (SAR) during lead optimization in drug discovery programs.

Applications in Drug Discovery: Researchers utilize this intermediate in the synthesis of a wide range of potential drug candidates. For instance, the chlorine atom at the 4-position can undergo nucleophilic substitution with amines to form novel amino-pyrido[2,3-d]pyrimidines, many of which have shown promise as kinase inhibitors or anticancer agents. The bromine atom at the 6-position is ideal for palladium-catalyzed cross-coupling reactions, enabling the attachment of aryl, heteroaryl, or alkyl groups, thereby expanding the chemical space that can be explored. The ability to efficiently buy this intermediate from chemical manufacturers facilitates rapid library synthesis for high-throughput screening (HTS).

Synthesis and Purity Considerations: The synthesis of 6-Bromo-4-chloropyrido[2,3-d]pyrimidine typically involves chemical transformations of simpler precursors. A common method involves chlorinating a precursor like 6-bromopyrido[2,3-d]pyrimidin-4(1H)-one. The resulting product is usually purified to a certain level, often stated as around 95% purity. For pharmaceutical R&D, the purity of intermediates is non-negotiable. Impurities can lead to side reactions, yield reduction, and the formation of undesired byproducts, complicating purification and potentially affecting the biological profile of the final synthesized compound. Therefore, when you purchase this chemical, always verify the manufacturer's quality control data and seek a detailed Certificate of Analysis (CoA).

Sourcing from Chemical Manufacturers: When it comes to procuring 6-Bromo-4-chloropyrido[2,3-d]pyrimidine, especially in research or pilot quantities, suppliers based in China often offer competitive pricing and a broad selection. Platforms and chemical directories list numerous manufacturers and suppliers. It is advisable for procurement specialists to compare quotes, inquire about lead times, and request sample quantities to assess product quality before placing larger orders. Understanding the typical price per kilogram or gram from different manufacturers helps in budgeting for R&D projects.

In conclusion, 6-Bromo-4-chloropyrido[2,3-d]pyrimidine (CAS 1215787-31-7) is a valuable and versatile building block in pharmaceutical R&D. Its unique structural features allow for diverse synthetic modifications, contributing to the discovery of new therapeutic agents. By focusing on understanding its role and ensuring quality sourcing from reputable chemical manufacturers, research teams can effectively leverage this intermediate to advance their drug development pipelines.