For professionals in the pharmaceutical and biotechnology sectors, the ability to procure high-quality chemical intermediates is foundational to successful research and product development. 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine-N-(succinyl) (sodium salt), identified by its CAS number 111613-33-3, is one such critical component, particularly valued for its role in advanced lipid formulations. This guide offers practical insights for those looking to buy this specialized lipid, emphasizing its applications, quality considerations, and supplier selection criteria.

Understanding the Product: 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine-N-(succinyl) (Sodium Salt)

This compound is a diacyl phospholipid with two oleic acid chains at the sn-1 and sn-2 positions of the glycerol backbone. The defining feature is its N-succinyl modified phosphoethanolamine headgroup, which provides a unique reactive site and influences the physicochemical properties of the lipid. Typically presented as a white to light yellow waxy solid, its purity, often exceeding 97.0%, is crucial for its intended applications. The primary driver for its use is in the formulation of Lipid Nanoparticles (LNPs), which are revolutionary for delivering nucleic acids like mRNA and siRNA. Its functional succinyl group contributes to the stability and efficacy of these complex delivery systems.

Applications Driving Demand: Why Researchers Buy Succinyl PE

The demand for 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(succinyl) (sodium salt) stems from its critical role in several high-impact areas:

  • Lipid Nanoparticle (LNP) Formulations: Essential for the development of mRNA vaccines, gene therapies, and other nucleic acid-based therapeutics, LNPs rely on precisely formulated lipid compositions for effective delivery. Succinyl PE is a key ingredient that can influence LNP stability and payload encapsulation.
  • Biomedical Research: Used in studies of cellular membranes, liposome engineering, and the development of targeted drug delivery systems. Its unique chemical structure makes it a valuable tool for investigating biological processes.
  • Pharmaceutical Intermediates: Serves as a building block in the synthesis of more complex pharmaceutical compounds and delivery vehicles.

Researchers and developers looking to buy this lipid are often focused on advancing therapeutic modalities, and thus require materials that meet exacting standards.

Key Procurement Considerations for Buyers

When you are ready to buy 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(succinyl) (sodium salt), several factors are paramount:

  • Purity and Lot Consistency: Always prioritize suppliers that guarantee high purity (e.g., ≥97.0%) and demonstrate lot-to-lot consistency. Request Certificates of Analysis (CoAs) for detailed specifications.
  • Supplier Reliability: Choose manufacturers with a proven track record in lipid synthesis and a robust quality management system. This includes investigating their production capacity and commitment to regulatory standards.
  • Pricing and Value: Compare quotes from multiple reputable suppliers. While price is a factor, consider the overall value, including quality, reliability, and customer support. Bulk purchase discounts are often available.
  • Technical Support and Documentation: A good supplier will provide comprehensive technical data, handling recommendations, and be responsive to inquiries.

Securing a dependable supply chain is vital for both ongoing research and potential commercialization. Manufacturers in established chemical markets, like China, often provide excellent sourcing options.

Conclusion

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine-N-(succinyl) (sodium salt) is a highly valuable lipid with significant implications for modern therapeutics and biomedical research. By carefully considering purity, consistency, supplier reliability, and cost-effectiveness, procurement professionals and researchers can make informed decisions when they need to buy this essential component. We are a leading manufacturer and supplier committed to delivering high-quality lipids to support your innovation. Contact us to discuss your specific needs and to secure your supply of this critical material.