For researchers and product developers in the life sciences and pharmaceutical sectors, the consistent availability of high-purity chemical intermediates is non-negotiable. Among these critical compounds is 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(succinyl) (sodium salt), commonly known by its CAS number 111613-33-3. This functionalized lipid is a cornerstone for advanced applications, particularly in drug delivery systems. This article serves as a comprehensive guide for those looking to buy or understand the procurement of this essential material.

Understanding CAS 111613-33-3: Properties and Applications

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine-N-(succinyl) (sodium salt) is a specialized phospholipid characterized by its diacyl-sn-glycero-3-phosphoethanolamine backbone, modified with a succinyl group attached to the ethanolamine nitrogen. This succinyl modification imparts unique properties, making it valuable for applications requiring specific charge characteristics or reactive functional groups. Its typical appearance is that of a white to light yellow waxy solid, and its high purity, often guaranteed at 97.0% or greater, is crucial for its efficacy in sensitive research and development projects. The primary application driving demand for this lipid is in the formulation of Lipid Nanoparticles (LNPs), which are revolutionizing the delivery of nucleic acid-based therapeutics, including mRNA vaccines and gene therapies. Its role extends to general biomedical research, where its amphipathic nature and functional group make it useful for studying membrane biophysics and developing novel drug conjugates.

The Importance of Purity and Consistency for Buyers

When sourcing chemicals like CAS 111613-33-3, purity is not merely a specification; it's a critical determinant of experimental success and product performance. Impurities can lead to unpredictable results, affect nanoparticle stability, and compromise the safety and efficacy of pharmaceutical products. Therefore, buyers must prioritize suppliers who can consistently deliver material meeting stringent purity standards. Lot-to-lot consistency is equally important, ensuring that formulation parameters and experimental conditions remain stable over time. A reliable manufacturer will provide comprehensive Certificates of Analysis (CoA) for each batch, detailing purity, composition, and other key physicochemical properties. This transparency is essential for due diligence when you are ready to buy.

Navigating the Supplier Landscape: What to Look For

The global market offers numerous suppliers for specialized lipids. However, not all suppliers are equal. For procurement managers and research scientists, identifying a trustworthy manufacturer and supplier involves looking for several key attributes: extensive experience in lipid synthesis and purification, a strong commitment to quality control, robust manufacturing capabilities, and excellent customer support. Geographical location can also play a role; suppliers in established chemical manufacturing hubs, such as China, often offer competitive pricing without compromising on quality, especially for intermediates like succinyl PE. When you plan to buy, research potential suppliers thoroughly, compare specifications, and request samples for preliminary evaluation. Understanding the manufacturer's production capacity is also important if you anticipate scaling up your research or production.

Cost-Effective Procurement Strategies for Succinyl PE

While quality is paramount, cost-effectiveness remains a significant consideration. Procuring CAS 111613-33-3 at a favorable price point can significantly impact project budgets, especially for large-scale R&D or commercial production. Buyers can often achieve better pricing by inquiring about bulk purchase discounts and establishing long-term supply agreements with their chosen manufacturer. Furthermore, understanding the total cost of ownership, which includes not just the per-unit price but also shipping, quality assurance, and potential downstream issues due to lower-quality materials, provides a more accurate financial picture. Consider contacting multiple suppliers for quotes to ensure you are getting the best value for your investment in this high-purity lipid.

Conclusion

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine-N-(succinyl) (sodium salt) (CAS 111613-33-3) is a critical component for cutting-edge research and development in the pharmaceutical and biotechnology sectors. By understanding its properties, prioritizing purity and consistency, and selecting a reliable manufacturer and supplier, procurement managers and researchers can ensure the success of their projects. We pride ourselves on being a leading supplier of high-purity lipids, committed to supporting scientific advancement. Contact us to learn more and to buy the high-quality succinyl PE you need.